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Risk Factors and Secondary Prevention in Women with Heart Disease: The Heart and Estrogen/progestin Replacement Study

Eric Vittinghoff, PhD; Michael G. Shlipak, MD, MPH; Paul D. Varosy, MD; Curt D. Furberg, MD, PhD; Christine C. Ireland, MPH; Steven S. Khan, MD; Roger Blumenthal, MD; Elizabeth Barrett-Connor, MD; Stephen Hulley, MD, MPH, Heart and Estrogen/progestin Replacement Study Research Group
[+] Article and Author Information

From the University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California; Wake Forest University School of Medicine, Winston-Salem, North Carolina; University of California, Los Angeles, Los Angeles, California; Johns Hopkins University, Baltimore, Maryland; and University of California, San Diego, San Diego, California.


Grant Support: By Wyeth-Ayerst Laboratories. Dr. Shlipak is funded by a Research Career Development Award from the Health Services Research and Development Service of the Veterans Affairs Administration.

Potential Financial Conflicts of Interest:Consultancies: C.D. Furberg; Honoraria: M.G. Shlipak, C.D. Furberg, S.S. Khan; Grants received: E. Vittinghoff, M.G. Shlipak, C.D. Furberg, C.C. Ireland, S.S. Khan, R. Blumenthal, E. Barrett-Connor, S. Hulley.

Requests for Single Reprints: Eric Vittinghoff, PhD, University of California, San Francisco, 74 New Montgomery, Suite 600, San Francisco, CA 94105.

Current Author Addresses: Dr. Vittinghoff, Ms. Ireland, and Dr. Hulley: University of California, San Francisco, 74 New Montgomery, Suite 600, San Francisco, CA 94105.

Drs. Shlipak and Varosy: Veterans Affairs Medical Center, 4150 Clement Street (111A1), San Francisco, CA 94121.

Dr. Furberg: Wake Forest University School of Medicine, One Medical Center Boulevard, Winston-Salem, NC 27157-1066.

Dr. Khan: Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Room 6215, Los Angeles, CA 90048-1804.

Dr. Blumenthal: Johns Hopkins University Hospital, 600 North Wolfe Street, Carnegie Room 538, Baltimore, MD 21287.

Dr. Barrett-Connor: University of California, San Diego, Stein Clinical Research Building 0607, CA 92093-0607.

Author Contributions: Conception and design: E. Vittinghoff, M.G. Shlipak, S. Hulley.

Analysis and interpretation of the data: E. Vittinghoff, M.G. Shlipak, P.D. Varosy, C.D. Furberg, S.S. Khan, S. Hulley.

Drafting of the article: E. Vittinghoff, M.G. Shlipak, P.D. Varosy, S.S. Khan, S. Hulley.

Critical revision of the article for important intellectual content: E. Vittinghoff, M.G. Shlipak, P.D. Varosy, C.D. Furberg, S.S. Khan, R. Blumenthal, E. Barrett-Connor, S. Hulley.

Final approval of the article: E. Vittinghoff, M.G. Shlipak, P.D. Varosy, C.D. Furberg, C.C. Ireland, S.S. Khan, R. Blumenthal, E. Barrett-Connor, S. Hulley.

Provision of study materials or patients: S.S. Khan, E. Barrett-Connor.

Statistical expertise: E. Vittinghoff, P.D. Varosy.

Obtaining of funding: E. Barrett-Connor, S. Hulley.

Administrative, technical, or logistic support: C.D. Furberg, C.C. Ireland, S.S. Khan, S. Hulley.

Collection and assembly of data: S.S. Khan.


Ann Intern Med. 2003;138(2):81-89. doi:10.7326/0003-4819-138-2-200301210-00007
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During an average of 4.1 years of follow-up in 1993 to 1998, 361 of 2763 women in HERS had nonfatal MI or died of CHD. Of the 232 women with nonfatal MI, 24 subsequently died of CHD. The 129 CHD deaths included 35 fatal MIs, 38 sudden deaths, 16 deaths from congestive heart failure or pulmonary edema, 24 deaths that were unwitnessed or occurred during sleep, and 16 deaths from other or unclassified CHD causes.

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Summary for Patients

Risk Factors and Treatment in Women with Coronary Artery Disease

The summary below is from the full report titled “Risk Factors and Secondary Prevention in Women with Heart Disease: The Heart and Estrogen/progestin Replacement Study.” It is in the 21 January 2003 issue of Annals of Internal Medicine (volume 138, pages 81-89). The authors are E Vittinghoff, MG Shlipak, PD Varosy, CD Furberg, CC Ireland, SS Khan, R Blumenthal, E Barrett-Connor, and S Hulley, for the Heart and Estrogen/progestin Replacement Study Research Group.

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