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Interferon Therapy after Tumor Ablation Improves Prognosis in Patients with Hepatocellular Carcinoma Associated with Hepatitis C Virus

Yasushi Shiratori, MD; Shuichiro Shiina, MD; Takuma Teratani, MD; Masatoshi Imamura, MD; Shun'taro Obi, MD; Shin'pei Sato, MD; Yukihiro Koike, MD; Haruhiko Yoshida, MD; and Masao Omata, MD
[+] Article and Author Information

From University of Tokyo, Tokyo, Japan.


Requests for Single Reprints: Yasushi Shiratori, MD, Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan; e-mail, shirato@cc.okayama-u.ac.jp.

Current Author Addresses: Dr. Shiratori, Department of Gastroenterology, Hepatology, and Infectious Diseases, Okayama University School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama-city, Okayama 700, Japan

Drs. Shiina, Teratani, Imamura, Obi, Sato, Koike, Yoshida, and Omata: Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.

Author Contributions: Conception and design: Y. Shiratori, S. Shiina, T. Teratani, M. Imamura, S. Obi, S. Sato, Y. Koike, H. Yoshida, M. Omata.

Analysis and interpretation of the data: Y. Shiratori, H. Yoshida.

Drafting of the article: Y. Shiratori.

Critical revision of the article for important intellectual content: Y. Shiratori, S. Shiina, T. Teratani, M. Imamura, S. Obi, S. Sato, Y. Koike, H. Yoshida, M. Omata.

Final approval of the article: Y. Shiratori, M. Omata.

Provision of study materials or patients: Y. Shiratori, S. Shiina, T. Teratani, M. Imamura, S. Obi, S. Sato, Y. Koike, M. Omata.

Statistical expertise: Y. Shiratori, H. Yoshida.

Obtaining of funding: Y. Shiratori, M. Omata.

Administrative, technical, or logistic support: Y. Shiratori, M. Omata.

Collection and assembly of data: Y. Shiratori, S. Shiina, T. Teratani, M. Imamura, S. Obi, S. Sato, Y. Koike.


Ann Intern Med. 2003;138(4):299-306. doi:10.7326/0003-4819-138-4-200302180-00008
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Patients with hepatocellular carcinoma and HCV infection with low viral loads (≤ 2 × 106 copies/mL) who underwent successful percutaneous ethanol injection therapy were enrolled in this study of combined tumor ablation and interferon therapy. Only patients with three or fewer lesions of hepatocellular carcinoma were included because complete necrosis of the nodules could be easily achieved (78, 10). Of the 74 patients enrolled, 49 were assigned to receive interferon therapy and 25 served as the control group (untreated group). Clinical profiles were similar in the two groups.

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Figure 1.
Schematic flow chart of enrolled patients.

HCC = hepatocellular carcinoma; HCV = hepatitis C virus; IFN = interferon.

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Grahic Jump Location
Figure 2.
Cumulative rate of development of new foci of hepatocellular carcinoma with respect to interferon ( IFN ) therapy (Kaplan–Meier method). TopMiddleBottom

. Rates of first new foci of hepatocellular carcinoma. . Rates of second recurrence of new foci of hepatocellular carcinoma. . Rates of third recurrence of new foci of hepatocellular carcinoma. Censoring times are indicated by the short vertical line segments.

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Grahic Jump Location
Figure 3.
Survival rate of patients with hepatocellular carcinoma with respect to interferon ( IFN ) treatment (Kaplan–Meier method).

Censoring times are indicated by the short vertical line segments.

Grahic Jump Location

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Summary for Patients

Interferon Therapy Improves Survival in Patients with Liver Cancer and Hepatitis C Virus Infection

The summary below is from the full report titled “Interferon Therapy after Tumor Ablation Improves Prognosis in Patients with Hepatocellular Carcinoma Associated with Hepatitis C Virus.” It is in the 18 February 2003 issue of Annals of Internal Medicine (volume 138, pages 299-306). The authors are Y Shiratori, S Shiina, T Teratani, M Imamura, S Obi, S Sato, Y Koike, H Yoshida, and M Omata.

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