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Single-Detector Helical Computed Tomography as the Primary Diagnostic Test in Suspected Pulmonary Embolism: A Multicenter Clinical Management Study of 510 Patients

Marco J.L. van Strijen, MD; Wouter de Monyé, MD; Jan Schiereck, MD; Gerard J. Kieft, MD; Martin H. Prins, MD; Menno V. Huisman, MD; Peter M.T. Pattynama, MD, Advances in New Technologies Evaluating the Localisation of Pulmonary Embolism (ANTELOPE) Study Group*
[+] Article and Author Information

From Leyenburg Ziekenhuis, The Hague; Leiden University Medical Center, Leiden; Utrecht Medical Center, Utrecht; and Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.


Acknowledgments: The results of this study are part of the results of the ANTELOPE Study Group (Advances in New Technologies Evaluating the Localisation of Pulmonary Embolism), a Dutch prospective multicenter trial on pulmonary embolism. The authors thank Annette van den Berg-Huijsmans, Gerda Labadie, and Ria Koolma for their help with the statistical analysis of the results and management of the data.

Grant Support: By grant D94-090 from the Dutch National Health Insurance Council (Ziekenfondsraad).

Requests for Single Reprints: Menno V. Huisman, MD, Department of General Internal Medicine, Room B3Q-84, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; e-mail, m.v.huisman@lumc.nl.

Current Author Addresses: Drs. van Strijen and Kieft: Department of Radiology, Leyenburg Ziekenhuis, Leyweg 275, 2545 CH The Hague, the Netherlands.

Dr. Monye': Department of Radiology, Leiden University Medical Cen-ter, PO Box 9600, 2300 RC Leiden, the Netherlands.

Dr. Schiereck: Department of Radiology, Utrecht Medical Center, Utre-cht, PO Box 85500, 3508 GA Utrecht, the Netherlands.

Dr. Prins: Department of Epidemiology, Academic Hospital Maastricht, PO Box 616, 6200 MD Maastricht, the Netherlands.

Dr. Huisman: Department of General Internal Medicine, Room B3Q-84, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.

Dr. Pattynama: Department of Radiology, Erasmus Medical Center Rot-terdam, PO Box 2040, 3000 CA Rotterdam, the Netherlands.

Author Contributions: Conception and design: M.J.L. van Strijen, G.J. Kieft, M.H. Prins, M.V. Huisman, P.M.T. Pattynama.

Analysis and interpretation of the data: M.J.L. van Strijen, M.H. Prins, M.V. Huisman.

Drafting of the article: M.J.L. van Strijen, M.V. Huisman, P.M.T. Pat-tynama. Critical revision of the article for important intellectual content: M.J.L. van Strijen, W. de Monye', G.J. Kieft, M.H. Prins, M.V. Huisman, P.M.T. Pattynama.

Final approval of the article: M.J.L. van Strijen, W. de Monye', J. Schiereck, G.J. Kieft, M.H. Prins, M.V. Huisman, P.M.T. Pattynama.

Provision of study materials or patients: M.J.L. van Strijen, W. de Monye', J. Schiereck, M.H. Prins, M.V. Huisman.

Statistical expertise: M.H. Prins.

Obtaining of funding: G.J. Kieft, M.H. Prins, P.M.T. Pattynama.

Administrative, technical, or logistic support: P.M.T. Pattynama. Collection and assembly of data: M.J.L. van Strijen, W. de Monye', J. Schiereck.


Ann Intern Med. 2003;138(4):307-314. doi:10.7326/0003-4819-138-4-200302180-00009
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During the recruitment period, 704 patients presented with suspected pulmonary embolism; 611 were eligible (Table 1). Of these eligible patients, 99 declined (or were unable) to give written informed consent. Thus, the study sample consisted of 512 patients (202 men and 310 women), and the median age was 55.1 years (range, 18 to 96 years) (Table 2). Age, sex, and recorded risk factors for venous thromboembolism were similar in the group of eligible patients and those who were enrolled.

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Grahic Jump Location
Figure.
Outcomes at initial presentation and at 12 weeks in 512 patients with clinically suspected pulmonary embolism.

CT = computed tomography; DVT = deep venous thrombosis.

Grahic Jump Location

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Summary for Patients

Detecting Clots in the Lungs

The summary below is from the full report titled “Single-Detector Helical Computed Tomography as the Primary Diagnostic Test in Suspected Pulmonary Embolism: A Multicenter Clinical Management Study of 510 Patients.” It is in the 18 February 2003 issue of Annals of Internal Medicine (volume 138, pages 307-314). The authors are MJL van Strijen, W de Monyé, J Schiereck, GJ Kieft, MH Prins, MV Huisman, and PMT Pattynama, for the Advances in New Technologies Evaluating the Localisation of Pulmonary Embolism (ANTELOPE) Study Group.

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