The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

The Impact of Protein Intake on Renal Function Decline in Women with Normal Renal Function or Mild Renal Insufficiency

Eric L. Knight, MD, MPH; Meir J. Stampfer, MD, DrPH; Susan E. Hankinson, RN, ScD; Donna Spiegelman, ScD; and Gary C. Curhan, MD, ScD
[+] Article, Author, and Disclosure Information

From Brigham and Women's Hospital, Harvard Medical School; and Massachusetts General Hospital, Harvard School of Public Health, Boston, Massachusetts.

Acknowledgments: The authors thank the participants of the Nurses' Health Study. They also thank Elaine Coughlan for carefully reviewing the statistical programming and manuscript content, Sue Malspeis for helping with the programming necessary to perform the measurement-error adjustment, Diane Feskanich for helping to interpret the food composition tables, Melissa Francis for assisting with manuscript preparation, and Walter Willett for reviewing the manuscript and making helpful suggestions.

Grant Support: By the National Institutes of Health (T32DK0740, T32DK07791, DK52866, CA87969, and HL34594).

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Eric L. Knight, MD, MPH, Channing Laboratory, Nurses' Health Study, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115; e-mail, elknight@partners.org.

Current Author Addresses: Drs. Knight, Hankinson, and Curhan: Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115.

Drs. Stampfer and Spiegelman: Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115.

Author Contributions: Conception and design: E.L. Knight, G.C. Curhan.

Analysis and interpretation of the data: E.L. Knight, M.J. Stampfer, S.E. Hankinson, D. Spiegelman, G.C. Curhan.

Drafting of the article: E.L. Knight, G.C. Curhan.

Critical revision of the article for important intellectual content: E.L. Knight, M.J. Stampfer, S.E. Hankinson, D. Spiegelman, G.C. Curhan.

Final approval of the article: E.L. Knight, M.J. Stampfer, S.E. Hankinson, D. Spiegelman, G.C. Curhan.

Provision of study materials or patients: G.C. Curhan.

Statistical expertise: E.L. Knight, M.J. Stampfer, D. Spiegelman, G.C. Curhan.

Obtaining of funding: G.C. Curhan.

Administrative, technical, or logistic support: E.L. Knight, M.J. Stampfer, S.E. Hankinson.

Collection and assembly of data: E.L. Knight, S.E. Hankinson, G.C. Curhan.

Ann Intern Med. 2003;138(6):460-467. doi:10.7326/0003-4819-138-6-200303180-00009
Text Size: A A A

Demographic, laboratory, and dietary information are presented in Table 1 according to baseline estimated GFR. The estimated mean GFR was lower at baseline and changed less during the study period than did the estimated creatinine clearance. Participants in the mild renal insufficiency group were 2 years older than those in the normal renal function group, and both groups had similar total protein intake. Absolute decline in estimated GFR was less pronounced in the renal insufficiency group than in the group with normal renal function.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

The Effect of Dietary Protein Intake on Kidney Function in Women with Normal or Mildly Abnormal Kidneys

The summary below is from the full report titled “The Impact of Protein Intake on Renal Function Decline in Women with Normal Renal Function or Mild Renal Insufficiency.” It is in the 18 March 2003 issue of Annals of Internal Medicine (volume 138, pages 460-467). The authors are EL Knight, MJ Stampfer, SE Hankinson, D Spiegelman, and GC Curhan.


Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.