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From the Double Helix to Genomic Medicine[dhelix]

William N. Kelley, MD
[+] Article, Author, and Disclosure Information

From University of Pennsylvania; Philadelphia, PA 19104

Potential Financial Conflicts of Interest:Stock ownership or options (other than mutual funds): Merck & Co., Inc., Beckman Coulter, Inc., GenVec, Inc.; Patents received: Viral-Mediated Gene Transfer System (patent 5,672,344).

Requests for Single Reprints: William N. Kelley, MD, University of Pennsylvania School of Medicine, Suite 757, BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104-6160; e-mail, kelleyw@mail.mail.med.upenn.edu.

Ann Intern Med. 2003;138(7):603-604. doi:10.7326/0003-4819-138-7-200304010-00019
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The monumental contribution of Watson and Crick—proposing the structure of DNA—is being celebrated this spring on the 50th anniversary of their classic publication in Nature(1). Expressed simply, clearly, and logically, their analysis was a signal event in the history of science. In the five decades that have followed, a series of truly remarkable discoveries have occurred throughout all of science based on the implications of their conclusions. While it is very difficult to quantify the effect of this progress on clinical medicine today or what it might be in the future, several observations may provide a perspective for the busy clinician.

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