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Survival Benefit of Initiating Antiretroviral Therapy in HIV-Infected Persons in Different CD4+ Cell Strata

Frank J. Palella Jr., MD; Maria Deloria-Knoll, PhD; Joan S. Chmiel, PhD; Anne C. Moorman, BSN, MPH; Kathleen C. Wood, BSN; Alan E. Greenberg, MD, MPH; Scott D. Holmberg, MD, MPH, the HIV Outpatient Study (HOPS) Investigators*
[+] Article and Author Information

From Northwestern University, Chicago, Illinois; National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia; and APACHE Medical Systems, Cerner Corporation, Vienna, Virginia.


Acknowledgment: The authors thank John P. Phair, MD, Professor Emeritus of Medicine, The Feinberg School of Medicine, Northwestern University, for his ongoing support, insight, and sage advice.

Grant Support: By the Centers for Disease Control and Prevention (contract 200-2001-00133), Atlanta, Georgia.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Frank J. Palella Jr., MD, Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, 676 North Saint Clair, Suite 200, Chicago, IL 60611; e-mail, f-palella@northwestern.edu.

Current Author Addresses: Dr. Palella: Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, 676 North Saint Clair, Suite 200, Chicago, IL 60611.

Drs. Deloria-Knoll and Chmiel: Department of Preventive Medicine, The Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611.

Ms. Moorman, Dr. Greenberg, and Dr. Holmberg: Centers for Disease Control and Prevention, Mailstop E-45, 1600 Clifton Road, Atlanta, GA 30333.

Ms. Wood: Cerner Corporation, 2800 Rockcreek Parkway, Kansas City, MO 64117.

Author Contributions: Conception and design: F.J. Palella, M. Deloria-Knoll, J.S. Chmiel, A.C. Moorman, S.D. Holmberg.

Analysis and interpretation of the data: F.J. Palella, M. Deloria-Knoll, J.S. Chmiel, A.C. Moorman, A.E. Greenberg, S.D. Holmberg.

Drafting of the article: F.J. Palella.

Critical revision of the article for important intellectual content: F.J. Palella, M. Deloria-Knoll, J.S. Chmiel, A.C. Moorman, A.E. Greenberg, S.D. Holmberg.

Final approval of the article: F.J. Palella, M. Deloria-Knoll, J.S. Chmiel, A.C. Moorman, K.C. Wood, A.E. Greenberg, S.D. Holmberg.

Provision of study materials or patients: F.J. Palella.

Statistical expertise: M. Deloria-Knoll, J.S. Chmiel.

Obtaining of funding: K.C. Wood.

Administrative, technical, or logistic support: F.J. Palella, A.C. Moorman, K.C. Wood, S.D. Holmberg.

Collection and assembly of data: F.J. Palella, A.C. Moorman, K.C. Wood, S.D. Holmberg.


Ann Intern Med. 2003;138(8):620-626. doi:10.7326/0003-4819-138-8-200304150-00007
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We evaluated data from 1464 HIV-infected HOPS participants. Of these patients, 596 who initiated ART had at least one additional CD4+ measurement after ART initiation, and 175 who delayed ART had at least one additional recorded CD4+ cell count in a higher stratum before ART initiation. We compared the demographic and baseline characteristics of patients described in this report to those of the larger overall group of HOPS participants and found no meaningful differences (data not shown).

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Summary for Patients

Immediate versus Delayed Treatment for HIV Infection

The summary below is from the full report titled “Survival Benefit of Initiating Antiretroviral Therapy in HIV-Infected Persons in Different CD4+Cell Strata.” It is in the 15 April 2003 issue of Annals of Internal Medicine (volume 138, pages 620-626). The authors are F.J. Palella Jr., M. Deloria-Knoll, J.S. Chmiel, A.C. Moorman, K.C. Wood, A.E. Greenberg, S.D. Holmberg, and the HIV Outpatient Study (HOPS) Investigators.

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