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Update on Parkinson Disease

Andrew Siderowf, MD; and Matthew Stern, MD
[+] Article, Author, and Disclosure Information

From University of Pennsylvania, Philadelphia, Pennsylvania.

Grant Support: Dr. Siderowf is supported by a career development award from the Agency for Healthcare Research and Quality (AHRQ K-08 HS00004).

Potential Financial Conflicts of Interest: Consultancies: M. Stern (Pharmacia Corp., GlaxoSmithKline); Honoraria: A. Siderowf (Pharmacia Corp.); Grant support: A. Siderowf (Medtronics, Inc., Pharmacia Corp.).

Requests for Single Reprints: Andrew Siderowf, MD, Parkinson's Disease and Movement Disorders Center, University of Pennsylvania, 330 South 9th Street, Philadelphia, PA 19107; e-mail, adsiderowf@pahosp.com.

Current Author Addresses: Drs. Siderowf and Stern: Parkinson's Disease and Movement Disorders Center, University of Pennsylvania, 330 South 9th Street, Philadelphia, PA 19107.

Ann Intern Med. 2003;138(8):651-658. doi:10.7326/0003-4819-138-8-200304150-00013
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Parkinson disease is the second most common neurodegenerative disease affecting older persons in the United States. The estimated prevalence of Parkinson disease is 100 to 200 per 100 000 persons older than 40 years of age (1). Historically, Parkinson disease has been unique among neurodegenerative disorders because of the presence of effective therapy based on replacement of dopamine (2). In the past several years, there have been developments in many areas related to Parkinson disease. In this Update, we focus on newer research on genetic and environmental factors relevant to the causes of Parkinson disease and emerging data regarding treatment. This research has moved the field closer to the elusive goals of understanding the mechanisms of cell death in Parkinson disease and designing rational therapies.

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