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Effects of an Angiotensin-Converting Enzyme Inhibitor on Residual Renal Function in Patients Receiving Peritoneal Dialysis: A Randomized, Controlled Study

Philip Kam-Tao Li, FRCP; Kai-Ming Chow, MBChB, MRCP(UK); Teresa Yuk-Hwa Wong, MBChB, MRCP(UK); Chi-Bon Leung, MBChB, MRCP(UK); and Cheuk-Chun Szeto, MD, MRCP(UK)
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From Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

The preliminary results of this study were presented at the 35th Annual Meeting of the American Society of Nephrology, 30 October–4 November 2002, Philadelphia, Pennsylvania.

Acknowledgment: The authors thank Ms. Wendy Tang for her clerical assistance and the nursing staff of Renal Unit, Prince of Wales Hospital, Shatin, Hong Kong, for their help in data collection.

Grant Support: In part by research accounts 6901031 and 6900570 from the Chinese University of Hong Kong and in part by Aventis Pharmaceuticals Limited.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Philip K.-T. Li, FRCP, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong; e-mail, philipli@cuhk.edu.hk.

Current Author Addresses: Drs. Li, Chow, Wong, Leung, and Szeto: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Ngan Shing Street, Shatin, Hong Kong, China.

Author Contributions: Conception and design: P.K.-T. Li.

Analysis and interpretation of the data: K.-M. Chow, C.-B. Leung, C.-C. Szeto.

Drafting of the article: C.-C. Szeto.

Critical revision of the article for important intellectual content: P.K.-T. Li.

Final approval of the article: P.K.-T. Li, T. Y.-H. Wong.

Provision of study materials or patients: P.K.-T. Li.

Statistical expertise: C.-C. Szeto.

Obtaining of funding: P.K.-T. Li.

Administrative, technical, or logistic support: P.K.-T. Li.

Collection and assembly of data: K.-M. Chow, T. Y.-H. Wong, C.-B. Leung, C.-C. Szeto.

Ann Intern Med. 2003;139(2):105-112. doi:10.7326/0003-4819-139-2-200307150-00010
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Figure 2 shows the trial profile. Thirty patients were enrolled in the ramipril group and 30 in the control group. Baseline clinical characteristics are shown in Table 1. Table 2 presents baseline renal function and indices of dialysis adequacy. The ramipril group had marginally more diabetic patients, higher body weights, lower net ultrafiltration from the peritoneal equilibration test, and lower baseline residual GFR than the control group. Blood pressure at baseline was nearly identical in the two groups, and the number of patients taking different types of antihypertensive agents at baseline was also similar in both groups. Two patients in the control group required an ACE inhibitor during the study period because of new-onset cardiovascular disease.

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Grahic Jump Location
Figure 1.
Kaplan–Meier estimation of patients in the ramipril group and control group who progressed to complete anuria.

Error bars denote SEs.

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Grahic Jump Location
Figure 2.
Randomization and patient flow in the trial.

CVD = cardiovascular disease.

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Grahic Jump Location
Figure 3.
Unadjusted mean residual glomerular filtration rate (GFR) at baseline and follow-up in the ramipril group and the control group.

Error bars denote SEs.

Grahic Jump Location




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Summary for Patients

Preventing Worsening Kidney Function in Patients Receiving Peritoneal Dialysis

The summary below is from the full report titled “Effects of an Angiotensin-Converting Enzyme Inhibitor on Residual Renal Function in Patients Receiving Peritoneal Dialysis. A Randomized, Controlled Study.” It is in the 15 July 2003 issue of Annals of Internal Medicine (volume 139, pages 105-112). The authors are P.K.-T. Li, K.-M. Chow, T.Y.-H. Wong, C.-B. Leung, and C.-C. Szeto.


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