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Is It Time To Proactively Switch Successful Antiretroviral Therapy? Carefully Check Your SWATCH

Michael Saag, MD
[+] Article and Author Information

From University of Alabama at Birmingham; Birmingham, AL 35294.


Potential Financial Conflicts of Interest:Consultancies: Abbott, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Hoffman-LaRoche, OrthoBiotech/Johnson & Johnson, Pfizer/Agouron, Schering-Plough, Shire Pharmaceutical, TherapyEdge, Tibotec/Virco, Trimeris, Virologic; Grants received: Abbott, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Hoffman-LaRoche, Ortho Biotech/Johnson & Johnson, Pfizer/Agouron, Pharmacia & Upjohn, Triangle Pharmaceuticals.

Requests for Single Reprints: Michael Saag, MD, University of Alabama at Birmingham, CCB Room 178, 908 20th Street South, Birmingham, AL 35294.


Ann Intern Med. 2003;139(2):148-149. doi:10.7326/0003-4819-139-2-200307150-00014
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The routine use of triple-drug antiretroviral therapy in the mid-1990s heralded the beginning of the highly active antiretroviral therapy (HAART) era in HIV therapeutics. With these potent regimens, viral replication in lymphatic tissue could be reduced almost completely, leading to levels of virus in plasma below assay detection limits (<50 copies/mL). This resulted in steady increases in CD4 cell counts, reductions in opportunistic infections, and a dramatic reduction in HIV-related mortality rates.

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