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Association of High Serum Ferritin Concentration with Glucose Intolerance and Insulin Resistance in Healthy People

Michael Haap, MD; Andreas Fritsche, MD; Heinz Joachim Mensing, MD; Hans-Ulrich Häring, MD; and Michael Stumvoll, MD
[+] Article and Author Information

From University of Tübingen; D-72076 Tübingen, Germany.


Grant Support: In part by grants from the Deutsche Forschungsgemeinschaft DFG (Stu 192/3-1 and FR 1561/1-1) and the European Union (QLRT-1999-00674).


Ann Intern Med. 2003;139(10):869-871. doi:10.7326/0003-4819-139-10-200311180-00029
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Figure.
Correlation of serum ferritin concentrations with 2-hour glucose concentration (top) in 538 nondiabetic persons and insulin sensitivity (bottom) in 257 nondiabetic persons.rPrPrPrPrPrPP

Data were derived from least-square linear regression analyses performed on log-transformed data. For 2-hour glucose concentration in all participants, men, and women, = 0.08 ( = 0.049), = 0.32 ( < 0.001), and = 0.13 ( = 0.002), respectively. For insulin sensitivity in all participants, men, and women, = −0.22 ( < 0.001), = −0.35 ( < 0.001), and = −0.22 ( = 0.02), respectively. Mean serum ferritin concentrations (±SE) were 154 ± 9 µg/L in men and 46 ± 2 µg/L in women ( < 0.001). To convert serum ferritin concentration from µg/dL to µg/L, multiply by 10.

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