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Sildenafil Improved Pulmonary Hypertension and Peripheral Blood Flow in a Patient with Scleroderma-Associated Lung Fibrosis and the Raynaud Phenomenon

Stephan Rosenkranz; Frank Diet; Thomas Karasch; Julia Weihrauch; Klaus Wassermann; and Erland Erdmann
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From Klinik III für Innere Medizin and Klinik und Poliklinik für Dermatologie; Universität zu Köln.

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Ann Intern Med. 2003;139(10):871-873. doi:10.7326/0003-4819-139-10-200311180-00030
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Effects of sildenafil treatment on pulmonary arterial pressure, 6-minute walk test, brain natriuretic peptide levels, and peripheral blood flow.A.B.C.D.RTupper panellower panel

Hemodynamic measurements of systolic and mean pulmonary arterial pressure during right-heart catheterization before, 80 minutes after, and 1 week after initiation of sildenafil treatment. Distance on a 6-minute walk test performed at baseline and after initiation of sildenafil treatment. Data represent mean values (±SD) from 3 independent 6-minute walk tests performed on separate days before and after initiation of sildenafil treatment. Brain natriuretic peptide levels at baseline and after 1 and 4 months of sildenafil treatment. Laser flux Doppler of the finger at room temperature ( ) and in warm water before ( ) and after ( ) initiation of sildenafil treatment.

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