0
Summaries for Patients |

Detecting Spread of Non–Small-Cell Lung Cancer within the Chest FREE

[+] Article and Author Information

The summary below is from the full report titled “Test Performance of Positron Emission Tomography and Computed Tomography for Mediastinal Staging in Patients with Non–Small-Cell Lung Cancer. A Meta-Analysis.” It is in the 2 December 2003 issue of Annals of Internal Medicine (volume 139, pages 879-892). The authors are M.K. Gould, W.G. Kuschner, C.E. Rydzak, C.C. Maclean, A.N. Demas, H. Shigemitsu, J.K. Chan, and D.K. Owens.


Ann Intern Med. 2003;139(11):I-18. doi:10.7326/0003-4819-139-11-200312020-00001
Text Size: A A A

What is the problem and what is known about it so far?

In the United States, lung cancer is the second most common cancer in both men and women. The most common type of lung cancer is non–small-cell lung cancer. Lung cancer occurs when abnormal cells in the lung divide without control. Sometimes the cancer cells invade nearby tissue and spread through the blood and lymph system to other parts of the body. Some of the first places that lung cancer cells invade are lymph nodes in the area between the lungs (mediastinum).

Doctors usually use scans, such as computed tomography (CT) scans or positron emission tomography (PET) scans, to see whether lung cancer has spread to mediastinal lymph nodes. A computer linked to an x-ray machine creates CT scans. These scans give a series of detailed pictures of body structures. The PET scan is a relatively new test that involves injecting a radioactive substance into a vein. Cancer cells take up and trap the substance more than do normal cells. The PET scan gives pictures of areas of the body that are “lit up” because cells in that area are rapidly trapping the radioactive substance. There are many studies that look at the ability of CT and PET scans to detect the spread of lung cancer to mediastinal lymph nodes.

Why did the researchers do this particular study?

To compare the accuracy of CT and PET scans for detecting spread of non–small-cell lung cancer to mediastinal lymph nodes.

Who was studied?

More than 2500 patients who had participated in 39 different studies.

How was the study done?

Rather than doing a new study, researchers looked at past studies that assessed the accuracy of PET or compared the accuracy of PET with CT for diagnosing spread of cancer to lymph nodes. All patients in the studies had non–small-cell lung cancer. Most patients had biopsies to definitively diagnose spread of cancer to mediastinal lymph nodes. The researchers summarized data from the different studies to see whether CT or PET was better in detecting nodes that did and did not show cancer.

What did the researchers find?

Positron emission tomography was more accurate than CT for identifying cancer spread to lymph nodes. Also, both true-positive and false-positive PET findings were more common in people with enlarged lymph nodes than in people with normal-sized lymph nodes.

What were the limitations of the study?

The study only assessed the ability of PET and CT to detect spread of cancer to mediastinal lymph nodes. Because PET and CT sometimes find spread of cancer in other parts or structures of the body, all of the potential benefits of the 2 tests weren't studied.

What are the implications of the study?

Positron emission tomography is more accurate than CT for mediastinal staging of non–small-cell lung cancer. Because PET has more false-positive findings in patients with enlarged nodes, positive findings need biopsy confirmation.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)