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The Prevalence of Nontraditional Risk Factors for Coronary Heart Disease in Patients with Chronic Kidney Disease

Paul Muntner, PhD; L. Lee Hamm, MD; John W. Kusek, PhD; Jing Chen, MD, MSc; Paul K. Whelton, MD, MSc; and Jiang He, MD, PhD
[+] Article, Author, and Disclosure Information

From Tulane University, New Orleans, Louisiana, and the National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland.

Grant Support: In part by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (U01 DK60963), and the COBRE Program of the National Center for Research Resources, National Institutes of Health (P20 RR17659-01). Dr. Muntner also received partial support for this work from a Scientist Development Award from the American Heart Association (0235134N).

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Jiang He, MD, PhD, Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Avenue SL18; e-mail, jhe@tulane.edu.

Current Author Addresses: Drs. Muntner, Hamm, Chen, Whelton, and He: Tulane University, 1430 Tulane Avenue, New Orleans, LA 70112.

Dr. Kusek: National Institutes of Health, 6707 Democracy Boulevard, Room 617, Bethesda, MD 20817.

Author Contributions: Conception and design: P. Muntner, L.L. Hamm, J. Chen, J. He.

Analysis and interpretation of the data: P. Muntner, J.W. Kusek, J. Chen, P.K. Whelton, J. He.

Drafting of the article: P. Muntner, J.W. Kusek, P.K. Whelton, J He.

Critical revision of the article for important intellectual content: L.L. Hamm, J.W. Kusek, J. Chen, P.K. Whelton, J. He.

Final approval of the article: P. Muntner, L.L. Hamm, J.W. Kusek, J. Chen, P.K. Whelton, J. He.

Statistical expertise: P. Muntner, J. He.

Administrative, technical, or logistic support: J. Chen, J. He.

Collection and assembly of data: P. Muntner.

Ann Intern Med. 2004;140(1):9-17. doi:10.7326/0003-4819-140-1-200401060-00006
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On average, participants with a lower estimated GFR were older, less likely to be current smokers, and more likely to be obese and have hypertension (Table 2). Mean high-density lipoprotein cholesterol levels were lower, whereas systolic blood pressure levels and body mass index were higher in patients with lower estimated GFRs.

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The prevalence of nontraditional risk factors for cardiovascular disease, standardized by age, sex, and race or ethnicity, in participants in the Third National Health and Nutrition Examination Survey by level of estimated glomerular filtration rate(GFR)(≥ 90, 60 to 89, and <60 mL/min per 1.73 m 2 [chronic kidney disease])

All prevalence was standardized to a population 44 years of age, 47% female, 11% non-Hispanic black, and 5% Mexican American. CRP = C-reactive protein.

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Summary for Patients

Associations of Newer Cardiac Risk Factors with Chronic Kidney Disease

The summary below is from the full report titled “The Prevalence of Nontraditional Risk Factors for Coronary Heart Disease in Patients with Chronic Kidney Disease.” It is in the 6 January 2004 issue of Annals of Internal Medicine (volume 140, pages 9-17). The authors are P. Muntner, L.L. Hamm, J.W. Kusek, J. Chen, P.K. Whelton, and J. He.


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