The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Low-Molecular-Weight Heparin Compared with Intravenous Unfractionated Heparin for Treatment of Pulmonary Embolism: A Meta-Analysis of Randomized, Controlled Trials

Daniel J. Quinlan, MBBS; Andrew McQuillan, MBBS; and John W. Eikelboom, MBBS
[+] Article, Author, and Disclosure Information

From King's College Hospital, London, United Kingdom; and Royal Perth Hospital and the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.

Acknowledgments: The authors thank the authors of primary studies included in our meta-analysis (J. Cade, I. Campbell, D. Conen, S. Findik, A. Gallus, C. Kirchmaier, P. Kuijer, S. Laporte, S. Medlicott, P. Prandoni, and C. Thery) and R. Bejuit and S. Combe from Aventis Pharma; S. Wurzinger and F. Misselwitz from Knoll Pharmaceuticals; E. Lindenstrøm and L. Thomassen from Leo Pharmaceuticals; J. Brom and H. Bachmann from Novartis Pharmaceuticals; J. Schoenfelder, C. Fellenius, and A. Holmqvist, for Pharmacia Corporation; and J.-E. Joire from Sanofi-Synthelabo for assistance in verifying the accuracy of the data and providing missing data.

Potential Financial Conflicts of Interest:Honoraria: D.J. Quinlan (Aventis, Sanofi-Synthelabo), J.W. Eikelboom (Aventis, Pharmacia, Sanofi-Synthelabo); Grants received: J.W. Eikelboom (Aventis, Sanofi-Synthelabo).

Requests for Single Reprints: John W. Eikelboom, MBBS, Department of Haematology, Royal Perth Hospital, Wellington Street, Perth WA 6001, Australia; e-mail, john.eikelboom@health.wa.gov.au.

Current Author Addresses: Dr. Quinlan: Department of Radiology, King's College Hospital, Denmark Hill, London, SE5 9RS, United Kingdom.

Drs. McQuillan and Eikelboom: Department of Haematology, Royal Perth Hospital, Wellington Street, Perth WA 6001, Australia.

Author Contributions: Conception and design: D.J. Quinlan, A. McQuillan, J. Eikelboom.

Analysis and interpretation of the data: D.J. Quinlan, A. McQuillan, J. Eikelboom.

Drafting of the article: D.J. Quinlan, A. McQuillan, J. Eikelboom.

Critical revision of the article for important intellectual content: D.J. Quinlan, A. McQuillan, J. Eikelboom.

Final approval of the article: D.J. Quinlan, A. McQuillan, J. Eikelboom.

Statistical expertise: J. Eikelboom.

Administrative, technical, or logistic support: J. Eikelboom.

Collection and assembly of data: D.J. Quinlan, A. McQuillan, J. Eikelboom.

Ann Intern Med. 2004;140(3):175-183. doi:10.7326/0003-4819-140-3-200402030-00008
Text Size: A A A

A protocol was prospectively developed in which the specific objectives, criteria for study selection, the approach to assessing study quality, primary and secondary outcomes, and statistical methods were defined.

First Page Preview

View Large
First page PDF preview


Grahic Jump Location
Figure 1.
Process of study selection

LMWH = low-molecular-weight heparin; PE = pulmonary embolism; RCT = randomized, controlled trial; UFH = unfractionated heparin.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Symptomatic venous thromboembolism at the end of treatment in trials comparing low-molecular-weight heparin (LMWH) with unfractionated heparin (UFH) for the treatment of acute pulmonary embolism

Data for the study by Hull and colleagues (32) are estimated from the published time-to-event curve. OR = odds ratio.

Grahic Jump Location




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Treatment of Pulmonary Embolism

The summary below is from the full report titled “Low-Molecular-Weight Heparin Compared with Intravenous Unfractionated Heparin for Treatment of Pulmonary Embolism. A Meta-Analysis of Randomized, Controlled Trials.” It is in the 3 February 2004 issue of Annals of Internal Medicine (volume 140, pages 175–183). The authors are D.J. Quinlan, A. McQuillan, and J.W. Eikelboom.


Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
[Venous thromboembolism in patients with Guillain-Barre syndrome]. Zh Nevrol Psikhiatr Im S S Korsakova ;116(5):13-18.
An Algorithmic Approach to Management of Venous Thromboembolism. Clin Appl Thromb Hemost Published online Jun 5, 2016;
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.