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Accuracy of Offspring Reports of Parental Cardiovascular Disease History: The Framingham Offspring Study

Joanne M. Murabito, MD, ScM; Byung-Ho Nam, PhD; Ralph B. D'Agostino Sr., PhD; Donald M. Lloyd-Jones, MD, ScM; Christopher J. O'Donnell, MD, MPH; and Peter W.F. Wilson, MD
[+] Article and Author Information

From the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts; Boston University, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts; and the National Heart, Lung, and Blood Institute, Bethesda, Maryland.


Grant Support: By the National Institutes of Health National Heart, Lung, and Blood Institute contract N01-HC-25195.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Joanne M. Murabito, MD, ScM, Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702-5827; e-mail, Joanne@fram.nhlbi.nih.gov.

Current Author Addresses: Drs. Murabito, Lloyd-Jones, O'Donnell, and Wilson: Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702-5827.

Drs. Nam and D'Agostino: Boston University Statistics and Consulting Unit, 100 Cummington Street, Boston, MA 02215.

Author Contributions: Conception and design: J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, P.W.F. Wilson.

Analysis and interpretation of the data: J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, P.W.F. Wilson.

Drafting of the article: J.M. Murabito, C.J. O'Donnell, P.W.F. Wilson.

Critical revision of the article for important intellectual content: J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, P.W.F. Wilson.

Final approval of the article: J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, P.W.F. Wilson.

Provision of study materials or patients: J.M. Murabito, C.J. O'Donnell, P.W.F. Wilson.

Statistical expertise: B.-H. Nam, R.B. D'Agostino Sr., P.W.F. Wilson.

Obtaining of funding: R.B. D'Agostino Sr., C.J. O'Donnell.

Administrative, technical, or logistic support: C.J. O'Donnell.

Collection and assembly of data: C.J. O'Donnell, J.M. Murabito, P.W.F. Wilson.


Ann Intern Med. 2004;140(6):434-440. doi:10.7326/0003-4819-140-6-200403160-00010
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Our study sample included 791 men and 837 women offspring reporters with a mean age of 57 years (range, 34 to 83 years). The mean age difference between parents and offspring reporters was 32 years for fathers and 29 years for mothers. Table 1 shows the prevalence of cardiovascular disease risk factors and outcomes in offspring reporters. More than one third of reporters had hypertension, fewer than 10% had diabetes mellitus, and 40% had high blood cholesterol levels. Offspring self-reports of cardiovascular risk factors and events compared with their research medical records were very reliable (all positive and negative predictive values were >75%, positive likelihood ratios were >6.0, and negative likelihood ratios were <1.0).

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Figure.
Offsprings' reports of cardiovascular risk factors and disease in their fathers.

Top. Positive predictive values. Bottom. Negative predictive values. MI = myocardial infarction.

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Summary for Patients

The Accuracy of Adult Patients' Reports of Their Parents' Medical Histories

The summary below is from the full report titled “Accuracy of Offspring Reports of Parental Cardiovascular Disease History: The Framingham Offspring Study.” It is in the 16 March 2004 issue of Annals of Internal Medicine (volume 140, pages 434-440). The authors are J.M. Murabito, B.-H. Nam, R.B. D'Agostino Sr., D.M. Lloyd-Jones, C.J. O'Donnell, and P.W.F. Wilson.

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