The full content of Annals is available to subscribers

Subscribe/Learn More  >
Letters |

Successful Treatment of Diffuse Alveolar Hemorrhage with Activated Factor VII

David Henke, MD, MPH; Ronald J. Falk, MD; and Don A. Gabriel, MD, PhD
[+] Article, Author, and Disclosure Information

From University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Acknowledgments: The authors thank Dr. Harold Roberts for help with the Discussion section and Jean Brown and Melissa Lawrence for editorial and secretarial assistance. They also thank the clinical teams who cared for the patients.

Ann Intern Med. 2004;140(6):493-494. doi:10.7326/0003-4819-140-6-200403160-00033
Text Size: A A A


Grahic Jump Location
Formation of the tenase complex and the prothrombinase complex.

Infused recombinant-activated human factor VII (rFVIIa) may initiate hemostasis by a tissue factor (TF)–dependent mechanism or by a TF-independent mechanism. Classically, TF expressed at an injury site activates factor VIIa (FVIIa). Then, FVIIa/TF activates both factor IX (FIX) and factor X (FX). Factor IXa (FIXa) and factor Xa (FXa) lead to stable thrombin formation by the assembly of the tenase complex (factor VIIIa [FVIIIa]/FIXa/FX) and the prothrombinase complex (factor Va [FVa]/FXa/factor II [FII]) on the surface of activated platelets. Infused rFVIIa may also initiate hemostasis by directly interacting with FIX on activated platelet surfaces. FIIa = factor IIa; FXIa = factor XIa.

Grahic Jump Location




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.