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Association of Statin Therapy with Outcomes of Acute Coronary Syndromes: The GRACE Study

Frederick A. Spencer, MD; Jeanna Allegrone, BA; Robert J. Goldberg, PhD; Joel M. Gore, MD; Keith A.A. Fox, MB, ChB, FRCP; Christopher B. Granger, MD; Rajendra H. Mehta, MD; David Brieger, MD, the GRACE Investigators*
[+] Article and Author Information

From University of Massachusetts Medical School, Worcester, Massachusetts; The University and The Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom; Duke University Medical Center, Durham, North Carolina; University of Michigan, Ann Arbor, Michigan; and Concord Hospital, Sydney, Australia.


Grant Support: GRACE is supported by an unrestricted educational grant from Aventis Pharma, Bridgewater, New Jersey.

Potential Financial Conflicts of Interest:Honoraria: K.A.A. Fox (Aventis, Bristol-Myers Squibb/Sanofi); Grants received: K.A.A. Fox (Aventis, Bristol-Myers Squibb/Sanofi), C.B. Granger (Aventis, Bristol-Myers Squibb/Sanofi, Organon, Novartis, AstraZeneca).

Requests for Single Reprints: Frederick A. Spencer, MD, Department of Medicine/Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655; e-mail, spencerf@ummhc.org.

Current Author Addresses: Drs. Spencer, Goldberg, and Gore and Ms. Allegrone: Department of Medicine/Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655.

Dr. Fox: The Royal Infirmary of Edinburgh, Department of Cardiology, Edinburgh, Scotland EH3 9WY, United Kingdom.

Dr. Granger: Duke University Medical Center, 2400 Pratt Street, Room 0311, Terrace Level, Box 3409, Durham, NC 27705.

Dr. Mehta: University of Michigan Health System, Division of Cardiology, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0366.

Dr. Brieger: Concord Repatriation Hospital, Coronary Care Unit, Level 3, Multi Building, Hospital Road, Concord NSW 2139, Australia.

Author Contributions: Conception and design: F.A. Spencer, J.M. Gore, C.B. Granger.

Analysis and interpretation of the data: F.A. Spencer, J. Allegrone, R.J. Goldberg, J.M. Gore, K.A.A. Fox.

Drafting of the article: F.A. Spencer, R.J. Goldberg.

Critical revision of the article for important intellectual content: F.A. Spencer, R.J. Goldberg, J.M. Gore, K.A.A. Fox, C.B. Granger, R.H. Mehta, D. Brieger.

Final approval of the article: F.A. Spencer, J. Allegrone, R.J. Goldberg, J.M. Gore, K.A.A. Fox, C.B. Granger, R.H. Mehta, D. Brieger.

Provision of study materials or patients: R.H. Mehta, D. Brieger.

Statistical expertise: J. Allegrone.

Obtaining of funding: J.M. Gore.

Administrative, technical, or logistic support: J.M. Gore.


Ann Intern Med. 2004;140(11):857-866. doi:10.7326/0003-4819-140-11-200406010-00006
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Full details of the GRACE rationale and methods have been published elsewhere and are outlined below (79).

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Figures

Grahic Jump Location
Figure.
Final diagnosis of acute coronary syndromes according to previous treatment with statins.

MI = myocardial infarction.

Grahic Jump Location

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Summary for Patients

Statin Therapy and the Outcomes during Hospitalization for Acute Coronary Syndromes

The summary below is from the full report titled “Association of Statin Therapy with Outcomes of Acute Coronary Syndromes: The GRACE Study.” It is in the 1 June 2004 issue of Annals of Internal Medicine (volume 140, pages 857-866). The authors are F.A. Spencer, J. Allegrone, R.J. Goldberg, J.M. Gore, K.A.A. Fox, C.B. Granger, R.H. Mehta, and D. Brieger, for the GRACE Investigators.

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