During the past 25 years, the Division of Diabetes Translation at the Centers for Disease Control and Prevention (CDC) has depended on available scientific findings to guide its public health programs. From 1979 through the early 1990s, the CDC focused on tertiary prevention, such as screening and treatment for diabetic retinopathy (18) and preventing the development of diabetic foot disorders and amputations (19). During this same period, most diabetes public health programs, including those supported by the CDC, provided actual clinical care for people who cannot participate in private health care systems. In 1993 and 1994, the CDC altered both the content and the methods of its public health programs. Because of the important Diabetes Control and Complication Trial (20), secondary prevention—that is, glycemic control—was added to existing tertiary prevention strategies. Furthermore, although there was (and still is) a need to assist individuals who are underinsured or uninsured, the CDC recognized that it was not applying its public health strategy for all people with diabetes in the United States. Consequently, primarily through its state-based Diabetes Prevention and Control Programs (21), the CDC began to develop a “model of influence,” or system-based, approach that involves national, regional, and local partners in ensuring adoption of the health care, community, organizational, and public policy systems—changes that ultimately would help improve the delivery and sustainability of good-quality diabetes care for everyone affected (22–23). While the CDC's “model of influence” approach to diabetes programs has continued, diabetes science also has progressed, resulting in the addition of cardiovascular disease prevention initiatives among patients with diabetes (9), as well as primary prevention of type 2 diabetes among those at high risk for developing this disease (24).