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Below-Knee Elastic Compression Stockings To Prevent the Post-Thrombotic Syndrome: A Randomized, Controlled Trial

Paolo Prandoni, MD, PhD; Anthonie W.A. Lensing, MD, PhD; Martin H. Prins, MD, PhD; Michela Frulla, MD; Antonio Marchiori, MD; Enrico Bernardi, MD, PhD; Daniela Tormene, MD; Laura Mosena, MD; Antonio Pagnan, MD; and Antonio Girolami, MD
[+] Article and Author Information

From University Hospital of Padua, Padua, Italy; and Academic Medical Center, Amsterdam, and Academic Hospital, Maastricht, the Netherlands.


Grant Support: By a grant from New Medical Service, Linea Flebologica Flebysan, Rovigo, Italy.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Paolo Prandoni, MD, Department of Medical and Surgical Sciences, 2nd Division of Internal Medicine, University Hospital of Padua, Via Ospedale Civile 105, 35128 Padua, Italy; e-mail, paoloprandoni@tin.it.

Current Author Addresses: Drs. Prandoni, Frulla, Marchiori, Bernardi, Tormene, Mosena, Pagnan, and Girolami: Department of Medical and Surgical Sciences, 2nd Division of Internal Medicine, University Hospital of Padua, Via Ospedale Civile 105, 35128 Padua, Italy.

Dr. Lensing: Center for Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.

Dr. Prins: Department of Clinical Epidemiology and Technology Assessment, Academic Hospital, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands.

Author Contributions: Conception and design: P. Prandoni, A.W.A. Lensing, M. Frulla.

Analysis and interpretation of the data: M.H. Prins, A. Marchiori, E. Bernardi.

Drafting of the article: P. Prandoni, A.W.A. Lensing, M.H. Prins, E. Bernardi.

Critical revision of the article for important intellectual content: A. Pagnan, A. Girolami.

Final approval of the article: P. Prandoni, A.W.A. Lensing, M.H. Prins, M. Frulla, A. Marchiori, E. Bernardi, D. Tormene, L. Mosena, A. Pagnan, A. Girolami.

Provision of study materials or patients: P. Prandoni, M. Frulla, D. Tormene, L. Mosena.

Statistical expertise: M.H. Prins, A. Marchiori, E. Bernardi.

Obtaining of funding: P. Prandoni.

Administrative, technical, or logistic support: P. Prandoni, D. Tormene, A. Pagnan, A. Girolami.

Collection and assembly of data: P. Prandoni, M. Frulla, D. Tormene, L. Mosena.


Ann Intern Med. 2004;141(4):249-256. doi:10.7326/0003-4819-141-4-200408170-00004
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The results of this randomized study show that elastic stockings are well tolerated and that their use reduces the overall incidence of the post-thrombotic syndrome from 49% to 26% and the overall incidence of severe sequelae from 12% to 3.5%. Only approximately 4 patients need to be treated with elastic compression stockings to prevent 1 additional case of the post-thrombotic syndrome. Increasing age and ipsilateral recurrent thrombosis were the only risk factors for the post-thrombotic syndrome.

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Figures

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Figure 1.
Flow diagram of the study.

DVT = deep venous thrombosis.

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Figure 2.
Cumulative incidence of the post-thrombotic syndrome in patients wearing elastic stockings and those in the control group.
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Summary for Patients

Can Compression Stockings Prevent the Post-Thrombotic Syndrome?

The summary below is from the full report titled “Below-Knee Elastic Compression Stockings To Prevent the Post-Thrombotic Syndrome. A Randomized, Controlled Trial.” It is in the 17 August 2004 issue of Annals of Internal Medicine (volume 141, pages 249-256). The authors are P. Prandoni, A.W.A. Lensing, M.H. Prins, M. Frulla, A. Marchiori, E. Bernardi, D. Tormene, L. Mosena, A. Pagnan, and A. Girolami.

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