Summaries for Patients |

Cardiac Resynchronization Therapy for Heart Failure FREE

[+] Article, Author, and Disclosure Information

The summary below is from the full report titled “Systematic Review: Cardiac Resynchronization in Patients with Symptomatic Heart Failure.” It is in the 7 September 2004 issue of Annals of Internal Medicine (volume 141, pages 381-390). The authors are F.A. McAlister, J.A. Ezekowitz, N. Wiebe, B. Rowe, C. Spooner, E. Crumley, L. Hartling, T. Klassen, and W. Abraham.

Ann Intern Med. 2004;141(5):I-64. doi:10.7326/0003-4819-141-5-200409070-00103
Text Size: A A A

What is the problem and what is known about it so far?

In heart failure, the heart does not pump blood as well as it should and fluid builds up in the lungs. The symptoms of heart failure include difficulty breathing, decreased ability to exercise, and leg swelling. Although many drugs help patients with heart failure, there is no cure. The condition is disabling and even fatal for many patients. In patients with heart failure, conduction of electrical impulses through the heart is often abnormal. This abnormal conduction, in turn, can lead to uncoordinated contraction of the ventricles, the large pumping chambers of the heart. Cardiac resynchronization is a newer heart failure treatment that uses a special type of pacemaker to synchronize the contraction of the ventricles. Cardiac resynchronization improves quality of life and exercise ability, but its effect on survival has been less clear. Only one study has been large enough to show that this therapy may improve survival.

Why did the authors do this review?

To combine all the information from studies of cardiac resynchronization therapy for heart failure.

How did the authors do this review?

The authors reviewed the published literature for studies that assigned patients at random to receive cardiac resynchronization therapy or usual medical therapy. The authors used a statistical method called meta-analysis to combine the results of the separate studies in order to better estimate the true effect of the therapy on patient outcomes. To evaluate the safety of cardiac resynchronization, they searched the literature for any study of cardiac resynchronization therapy. For the review of the safety of this therapy, the included studies did not have to involve random assignment to resynchronization or medical therapy.

What did the authors find?

For the estimates of effect on patient outcomes, the authors identified 9 studies that included 3216 patients with heart failure. All patients in these studies had moderately severe, symptomatic heart failure and an electrocardiogram abnormality called a prolonged QRS duration. After combining the results of these 9 studies, the authors concluded that cardiac resynchronization improved quality of life, exercise ability, hospitalization for heart failure, and survival. The authors found 18 studies for the safety analysis. These studies suggested that pacemaker placement was successful in about 90% of patients and that few patients died while the pacemaker was being implanted. However, over the 6 months after cardiac resynchronization therapy, the pacemaker dislodged from proper placement in 9% of patients and malfunctioned in 7%.

What are the implications of the review?

In selected patients with heart failure, cardiac resynchronization therapy improves outcomes. However, problems can occur in the months after pacemaker placement.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.