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The Effect of Long-Term Intake of cis Unsaturated Fats on the Risk for Gallstone Disease in Men: A Prospective Cohort Study

Chung-Jyi Tsai, MD, ScD; Michael F. Leitzmann, MD, DrPH; Walter C. Willett, MD, DrPH; and Edward L. Giovannucci, MD, ScD
[+] Article and Author Information

From Channing Laboratory, Harvard Medical School, Brigham and Women's Hospital, and Harvard School of Public Health, Boston, Massachusetts.


Acknowledgments: The authors thank the participants of the Health Professionals Follow-up Study for their continued cooperation and participation. They also thank all the research staff in the study for their expert help.

Grant Support: By research grants (CA55075 and DK46200) from the National Institutes of Health.

Potential Financial Conflicts of Interest: None disclosed.

Corresponding Author: Chung-Jyi Tsai, MD, ScD, Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, 800 Rose Street, MN649, Lexington, KY 40536-0298; e-mail, hpcjt@channing.harvard.edu.

Current Author Addresses: Dr. Tsai: Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, 800 Rose Street, MN649, Lexington, KY 40536-0298.

Dr. Leitzmann: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892.

Drs. Willett and Giovannucci: Harvard Medical School, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115.

Author Contributions: Conception and design: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.

Analysis and interpretation of the data: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.

Drafting of the article: C.-J. Tsai, M.F. Leitzmann.

Critical revision of the article for important intellectual content: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.

Final approval of the article: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.

Provision of study materials or patients: M.F. Leitzmann, W.C. Willett.

Statistical expertise: C.-J. Tsai, M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.

Obtaining of funding: W.C. Willett.

Administrative, technical, or logistic support: W.C. Willett.

Collection and assembly of data: M.F. Leitzmann, W.C. Willett, E.L. Giovannucci.


Ann Intern Med. 2004;141(7):514-522. doi:10.7326/0003-4819-141-7-200410050-00007
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Most participants in this cohort were white (>91%). We first examined the crude distribution of relevant covariates according to average levels of both polyunsaturated and monounsaturated fats consumption among the participants (Table 1). At baseline in 1986, the median intakes of polyunsaturated and monounsaturated fats varied nearly 2-fold between the highest and lowest quintiles in the study sample. Men with a higher intake of polyunsaturated fat consumed less carbohydrate but had higher intakes of trans fat (see Glossary) and saturated fat. Men who reported a higher polyunsaturated fat intake tended to be more sedentary, to be less likely to be current smokers, and to drink less alcohol. Men with a higher intake of monounsaturated fat had less carbohydrate and fiber but had higher intakes of trans fat and saturated fat. Men who reported a higher monounsaturated fat intake tended to drink less alcohol, were more likely to be current smokers, and were less physically active.

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Summary for Patients

Dietary Fat and Risk for Gallstone Disease in Men

The summary below is from the full report titled “The Effect of Long-Term Intake of cis Unsaturated Fats on the Risk for Gallstone Disease in Men. A Prospective Cohort Study.” It is in the 5 October 2004 issue of Annals of Internal Medicine (volume 141, pages 514-522). The authors are C.-J. Tsai, M.F. Leitzmann, W.C. Willett, and E.L. Giovannucci.

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