The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Long-Term Protection of Hepatitis B Vaccine: Lessons from Alaskan Experience after 15 Years

Ding-Shinn Chen, MD
[+] Article, Author, and Disclosure Information

From National Taiwan University College of Medicine, Taipei 100, Taiwan.

Grant Support: By the Department of Health, Taiwan, and National Science Council, Taiwan.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Ding-Shinn Chen, MD, National Taiwan University College of Medicine, 1 Jen-Ai Road, Section 1, Taipei 100, Taiwan; e-mail, dean@ha.mc.ntu.edu.tw.

Ann Intern Med. 2005;142(5):384-385. doi:10.7326/0003-4819-142-5-200503010-00014
Text Size: A A A

Hepatitis B virus (HBV) is highly infectious and causes serious health problems worldwide. Approximately one third of the world's population has been infected, and about 400 million people have become chronic carriers (12). The infection results in a wide spectrum of liver diseases, ranging from hyperacute fulminant hepatitis to refractory hepatic cirrhosis and hepatocellular carcinoma (35). Infection that occurs at a young age frequently results in chronic carriage of the virus. In contrast, only a small proportion of patients become chronic carriers if they contract the infection in adolescence or adulthood. Once the infection becomes chronic, HBV or part of the viral genome usually persists in the liver for the carrier's lifetime (5). The carriers are not only reservoirs of the virus but also victims of chronic liver diseases themselves (3). Thus, control of HBV infection, especially in terms of preventing chronic carriage of the virus, is extremely important.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.