Colorectal cancer is a leading cause of cancer and of death from cancer in the United States. Risk factors include physical inactivity, a low-fiber diet, and having a family member with this type of cancer. Some data suggest that low-grade inflammation may also increase the risk for colorectal cancer. C-reactive protein (CRP) is a protein in the blood that increases when inflammation is present in the body. If inflammation increases a person's risk for developing colorectal cancer, higher CRP levels might be a sign of that higher risk.