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Brief Communication: Duration of Platelet Dysfunction after a 7-Day Course of Ibuprofen

Neil A. Goldenberg, MD; Linda Jacobson, MT; and Marilyn J. Manco-Johnson, MD
[+] Article and Author Information

From the Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, Aurora, Colorado.


Acknowledgments: The authors thank Chris Bombardier for assistance in study coordination and Chris McKelvey and Sue Hurwitz for their technical expertise in performing the PFA-100 testing. They also thank William E. Hathaway, MD, and Philip Altus, MD, for valued commentary on the manuscript and the study participants for their contribution to this research.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Neil Goldenberg, MD, The Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, PO Box 6507, Mail Stop F416, Aurora, CO 80045-0507; e-mail, neil.goldenberg@uchsc.edu.

Current Author Addresses: Dr. Goldenberg, Ms. Jacobson, and Dr. Manco-Johnson: Mountain States Regional Hemophilia and Thrombosis Center, University of Colorado Health Sciences Center, PO Box 6507, Mail Stop F416, Aurora, CO 80045-0507.

Author Contributions: Conception and design: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.

Analysis and interpretation of the data: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.

Drafting of the article: N.A. Goldenberg, L. Jacobson.

Critical revision of the article for important intellectual content: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.

Final approval of the article: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.

Provision of study materials or patients: N.A. Goldenberg, M.J. Manco-Johnson.

Statistical expertise: N.A. Goldenberg.

Obtaining of funding: M.J. Manco-Johnson (local funding).

Administrative, technical, or logistic support: N.A. Goldenberg, L. Jacobson, M.J. Manco-Johnson.

Collection and assembly of data: N.A. Goldenberg, L. Jacobson.


Ann Intern Med. 2005;142(7):506-509. doi:10.7326/0003-4819-142-7-200504050-00009
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The Table shows demographic characteristics of the participants and results of serial PFA-100 testing; the Figure also displays the PFA-100 results. Collagen/epinephrine testing by PFA-100 is sensitive to both intrinsic (that is, congenital) and acquired (for example, drug-induced) platelet dysfunction, and therefore is typically performed in initial screening. In contrast, collagen/ADP testing is insensitive to acquired dysfunction and thus is performed to confirm intrinsic defects. All collagen/ADP results were normal in this study, and the closure times discussed here pertain to collagen/epinephrine testing.

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Figures

Grahic Jump Location
Figure.
Graph of PFA (platelet function analyzer)-100 collagen/epinephrine closure times (seconds) in 11 healthy adults measured at baseline and serially after the last dose of a 7-day course of regular ibuprofen use at standard adult doses (600 mg orally every 8 hours).

Data points for individuals taking estrogen-containing contraceptives are connected by dashed lines, while all others are connected by continuous lines. The heavy line connects the median value at each time point. The lightly shaded region denotes the normal range of closure times. The darkly shaded vertical bar indicates the 7-day course of ibuprofen.

Grahic Jump Location

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Summary for Patients

Platelet Function after Taking Ibuprofen for 1 Week

The summary below is from the full report titled “Brief Communication: Duration of Platelet Dysfunction after a 7-Day Course of Ibuprofen.” It is in the 5 April 2005 issue of Annals of Internal Medicine (volume 142, pages 506-509). The authors are N.A. Goldenberg, L. Jacobson, and M.J. Manco-Johnson.

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