0
Summaries for Patients |

Platelet Function after Taking Ibuprofen for 1 Week FREE

[+] Article and Author Information

The summary below is from the full report titled “Brief Communication: Duration of Platelet Dysfunction after a 7-Day Course of Ibuprofen.” It is in the 5 April 2005 issue of Annals of Internal Medicine (volume 142, pages 506-509). The authors are N.A. Goldenberg, L. Jacobson, and M.J. Manco-Johnson.


Ann Intern Med. 2005;142(7):I-54. doi:10.7326/0003-4819-142-7-200504050-00004
Text Size: A A A

What is the problem and what is known about it so far?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Many people take ibuprofen or other NSAIDs for headache, musculoskeletal problem, and other types of pain. Platelets are the blood cells that help the blood to clot. Ibuprofen and other NSAIDs may affect the way platelets work and could interfere with normal blood clotting. Blood clotting is very important during surgery, so many doctors advise patients to stop taking ibuprofen and other NSAIDs at least 1 week before surgery. However, the effect of NSAIDs on platelets is temporary. No studies directly support the recommendation to stop the drugs 7 days before surgery.

Why did the researchers do this particular study?

To see how long it took platelets to work normally after people stopped taking ibuprofen.

Who was studied?

11 healthy adult volunteers. These volunteers were not scheduled to have surgery.

How was the study done?

The volunteers took ibuprofen, 600 mg by mouth, every 8 hours for 7 days and then stopped taking the drug. The researchers tested platelets before the participants started taking ibuprofen and again 40 minutes, 8 hours, and 24 hours after they stopped taking the drug. The researchers tested platelets by measuring the ability of platelets to stick together (platelets need to stick together for normal blood clotting).

What did the researchers find?

All of the volunteers had normal platelet function before starting ibuprofen. Of the 11 volunteers, 7 had abnormal platelet function 40 minutes after the last dose of ibuprofen. However, all patients had normal platelet function 24 hours after the last ibuprofen dose.

What were the limitations of the study?

This study measured a test of platelet function in healthy volunteers rather than bleeding during surgery in actual patients. The researchers studied only ibuprofen, and the results may not apply to other NSAIDs.

What are the implications of the study?

Platelet function normalizes within 24 hours of the last dose of ibuprofen in healthy volunteers. This suggests that it may not be necessary for people who take ibuprofen to stop it a week before surgery.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
PubMed Articles

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)