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Brief Communication: High Incidence of Venous Thrombotic Events among Patients with Wegener Granulomatosis: The Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study

Peter A. Merkel, MD, MPH; Grace H. Lo, MD; Janet T. Holbrook, PhD, MPH; Andrea K. Tibbs, BS; Nancy B. Allen, MD; John C. Davis Jr, MD, MPH; Gary S. Hoffman, MD; W. Joseph McCune, MD; E. William St. Clair, MD; Ulrich Specks, MD; Robert Spiera, MD; Michelle Petri, MD, MPH; John H. Stone, MD, MPH, Wegener's Granulomatosis Etanercept Trial Research Group*
[+] Article and Author Information

From Boston University, Boston, Massachusetts; Johns Hopkins University, Baltimore, Maryland; Duke University, Durham, North Carolina; University of California, San Francisco, San Francisco, California; Cleveland Clinic Foundation, Cleveland, Ohio; University of Michigan, Ann Arbor, Michigan; Mayo Clinic, Rochester, Minnesota; and Beth Israel Medical Center, New York, New York.


Grant Support: By the National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases (contract no. N01-AR-9-2240 and center grant AR47785); U.S. Food and Drug Administration, Office of Orphan Products (grant no. FD-R-001652-01); General Clinical Research Center grants M01-RRO-00533 (Boston University), M01-RRO-0042 (The University of Michigan), M01-RR-30 (Duke University), and M01-RRO-2719 (Johns Hopkins University School of Medicine), from the National Center for Research Resources, National Institutes of Health (NIAMS-NIH AR2224); and Amgen Corporation, Thousand Oaks, California. Drs. Merkel, St. Clair, and Stone are partly supported by a Mid-Career Development Awards in Clinical Investigation (NIH-NIAMS K24 AR2224-01A1, K24 AR049185-01, and K24 AR049185-01).

Potential Financial Conflicts of Interest: Grants received: E.W. St. Clair (Amgen Corp.).

Requests for Single Reprints: Peter A. Merkel, MD, MPH, Boston University School of Medicine, Vasculitis Center, E-5, 715 Albany Street, Boston, MA 02118; e-mail, pmerkel@bu.edu.

Current Author Addresses: Drs. Merkel and Lo: Boston University School of Medicine, Vasculitis Center, E-5, 715 Albany Street, Boston, MA 02118.

Dr. Holbrook and Ms. Tibbs: Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205.

Dr. Allen: Duke University Medical Center, Box 3440, Durham, NC 27710.

Dr. Davis: University of California, San Francisco, 533 Parnassus Avenue, Box 0633, San Francisco, CA 94143.

Dr. Hoffman: The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.

Dr. McCune: University of Michigan, Taubman Center, Room 3918-0358, Ann Arbor, MI 48109.

Dr. St. Clair: Duke University Medical Center, Box 3874, Durham, NC 27710.

Dr. Specks: Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Dr. Spiera: Beth Israel Medical Center, 170 East End Avenue, New York, NY 10128.

Dr. Petri: Johns Hopkins Unversity School of Medicine, 1830 East Monument Street, #7500, Baltimore, MD 21205.

Dr. Stone: Johns Hopkins Vasculitis Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224.

Author Contributions: Conception and design: P.A. Merkel, G.H. Lo, J.T. Holbrook, G.S. Hoffman, E.W. St. Clair, U. Specks, R. Spiera, J.H. Stone.

Analysis and interpretation of the data: P.A. Merkel, G.H. Lo, J.T. Holbrook, A.K. Tibbs, J.C. Davis Jr., G.S. Hoffman, W.J. McCune, E.W. St. Clair, J.H. Stone.

Drafting of the article: P.A. Merkel, G.H. Lo, J.T. Holbrook, J.C. Davis Jr., M. Petri, J.H. Stone.

Critical revision of the article for important intellectual content: P.A. Merkel, G.H. Lo, J.T. Holbrook, N.B. Allen, J.C. Davis Jr., G.S. Hoffman, W.J. McCune, E.W. St. Clair, U. Specks, R. Spiera, J.H. Stone.

Final approval of the article: P.A. Merkel, G.H. Lo, J.T. Holbrook, N.B. Allen, J.C. Davis Jr., G.S. Hoffman, W.J. McCune, E.W. St. Clair, U. Specks, R. Spiera, J.H. Stone.

Provision of study materials or patients: P.A. Merkel, N.B. Allen, J.C. Davis Jr., G.S. Hoffman, W.J. McCune, E.W. St. Clair, U. Specks, R. Spiera, M. Petri, J.H. Stone.

Statistical expertise: P.A. Merkel, J.T. Holbrook.

Obtaining of funding: P.A. Merkel, J.T. Holbrook, J.H. Stone.

Administrative, technical, or logistic support: P.A. Merkel, J.T. Holbrook, J.C. Davis Jr., G.S. Hoffman.

Collection and assembly of data: P.A. Merkel, J.C. Davis Jr., G.S. Hoffman, W.J. McCune, E.W. St. Clair, U. Specks, R. Spiera, M. Petri, J.H. Stone.


Ann Intern Med. 2005;142(8):620-626. doi:10.7326/0003-4819-142-8-200505030-00011
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To our knowledge, our study is the first to investigate the incidence of VTE in Wegener granulomatosis using a large, well-characterized study cohort and to identify deep venous thrombosis as an important clinical feature of Wegener granulomatosis.

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Figures

Grahic Jump Location
Figure.
Time to first venous thrombotic event (VTE) among patients with Wegener granulomatosis.

All patients had active disease at time 0.

Grahic Jump Location

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Summary for Patients

Venous Thrombosis in Wegener Granulomatosis

The summary below is from the full report titled “Brief Communication: High Incidence of Venous Thrombotic Events among Patients with Wegener Granulomatosis: The Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.” It is in the 19 April 2005 issue of Annals of Internal Medicine (volume 142, pages 620-626). The authors are P.A. Merkel, G.H. Lo, J.T. Holbrook, A.K. Tibbs, N.B. Allen, J.C. Davis Jr., G.S. Hoffman, W.J. McCune, E.W. St. Clair, U. Specks, R. Spiera, M. Petri, and J.H. Stone, for The Wegener's Granulomatosis Etanercept Trial Research Group.

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