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Impaired Fasting Glucose and Cardiovascular Outcomes in Postmenopausal Women with Coronary Artery Disease

Alka M. Kanaya, MD; David Herrington, MD, MHS; Eric Vittinghoff, PhD; Feng Lin, MS; Vera Bittner, MD, MSPH; Jane A. Cauley, DrPH; Stephen Hulley, MD; and Elizabeth Barrett-Connor, MD
[+] Article and Author Information

From University of California, San Francisco, San Francisco, California; Wake Forest University School of Medicine, Winston-Salem, North Carolina; University of Alabama at Birmingham, Birmingham, Alabama; University of Pittsburgh, Pittsburgh, Pennsylvania; and University of California, San Diego, La Jolla, California.


Acknowledgments: The authors thank members of the HERS Coordinating Center and the Executive Committee for their review and recommended revisions.

Grant Support: By National Institutes of Health grants 5 K12 AR47659 and P30–AG15272 (Dr. Kanaya). Wyeth-Ayerst Research funded the Heart and Estrogen/progestin Replacement Study.

Potential Financial Conflicts of Interest: Honoraria: J.A. Cauley (Eli Lilly Inc., Merck & Co. Inc., Novartis); Grants received: E. Vittinghoff (Wyeth), V. Bittner (Wyeth), J.A. Cauley (Eli Lilly Inc., Merck & Co. Inc., Pfizer Inc., Novartis), E. Barrett-Connor (National Institutes of Health); Other: J.A. Cauley (Eli Lilly Inc., Merck & Co. Inc.).

Requests for Single Reprints: Alka M. Kanaya, MD, Women's Health Clinical Research Center, 1635 Divisadero Street, Suite 600, San Francisco, CA 94115; e-mail, alkak@itsa.ucsf.edu.

Current Author Addresses: Drs. Kanaya and Vittinghoff: Women's Health Clinical Research Center, University of California, San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 94115.

Dr. Herrington: Wake Forest University School of Medicine, One Medical Center Boulevard, Winston-Salem, NC 27157-1066.

Dr. Hulley and Ms. Lin: Prevention Sciences Group, 74 New Montgomery Street, Suite 600, San Francisco, CA 94105.

Dr. Bittner: University of Alabama at Birmingham, Division of Cardiovascular Disease, 701 19th Street South, LHRB 310, Birmingham, AL 35294.

Dr. Cauley: University of Pittsburgh, 130 DeSoto Street, A524, Pittsburgh, PA 15261.

Dr. Barrett-Connor: Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, Stein Clinical Research Building, La Jolla, CA 92093-0607.

Author Contributions: Conception and design: A.M. Kanaya, D. Herrington, S. Hulley.

Analysis and interpretation of the data: A.M. Kanaya, D. Herrington, E. Vittinghoff, F. Lin, V. Bittner, J.A. Cauley, S. Hulley, E. Barrett-Connor.

Drafting of the article: A.M. Kanaya, D. Herrington, S. Hulley.

Critical revision of the article for important intellectual content: A.M. Kanaya, D. Herrington, E. Vittinghoff, V. Bittner, J.A. Cauley, S. Hulley, E. Barrett-Connor.

Final approval of the article: A.M. Kanaya, D. Herrington, E. Vittinghoff, F. Lin, V. Bittner, J.A. Cauley, S. Hulley, E. Barrett-Connor.

Provision of study materials or patients: D. Herrington, V. Bittner, S. Hulley.

Statistical expertise: E. Vittinghoff, F. Lin, S. Hulley.

Obtaining of funding: A.M. Kanaya, S. Hulley.

Administrative, technical, or logistic support: A.M. Kanaya, S. Hulley.

Collection and assembly of data: A.M. Kanaya, V. Bittner, E. Barrett-Connor.


Ann Intern Med. 2005;142(10):813-820. doi:10.7326/0003-4819-142-10-200505170-00006
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At baseline, 734 (27%) women were classified as having diabetes, 218 (8%) had a fasting glucose level of 6.1 to 6.9 mmol/L (110 to 125 mg/dL), 480 (17%) had a fasting glucose level of 5.6 to 6.0 mmol/L (100 to 109 mg/dL), and 1331 (48%) had a fasting glucose level less than 5.6 mmol/L (<100 mg/dL). Only 94 (13%) of the 734 women with diabetes were classified as having diabetes solely on the basis of an elevated fasting glucose test. Four hundred seventy-nine (65%) were taking a diabetes medication, and the remaining 161 (22%) reported a physician diagnosis of diabetes but were not taking a diabetes medication.

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Summary for Patients

Are High Sugar Levels Associated with New Cardiovascular Events in Postmenopausal Women Who Have Already Had a Heart Attack?

The summary below is from the full report titled “Impaired Fasting Glucose and Cardiovascular Outcomes in Postmenopausal Women with Coronary Artery Disease.” It is in the 17 May 2005 issue of Annals of Internal Medicine (volume 142, pages 813-820). The authors are A.M. Kanaya, D. Herrington, E. Vittinghoff, F. Lin, V. Bittner, J.A. Cauley, S. Hulley, and E. Barrett-Connor.

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