We have described our approach to identification, appraisal, and presentation of systematic reviews of economic analyses. We illustrated this approach using a case example of CRC screening. Our example illustrates the promise, difficulties, and current limitations of the use of economic analyses by health care decision makers. We, and others, have demonstrated that, at least for some well-studied topics, investigators can identify relevant articles, extract key information, report results, and consider reasons for observed differences between studies (3, 5, 9). In short, systematic reviews of economic analyses can provide decision makers with important information for policy decisions, but systematic reviews published to date have not used consistent methods for identifying or evaluating economic analyses (9).