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Clinical Guidelines |

Screening for HIV: Recommendation Statement FREE

U.S. Preventive Services Task Force*
[+] Article and Author Information

From the U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland.


Disclaimer: Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.

Requests for Single Reprints: Reprints are available from the USPSTF Web site (http://www.preventiveservices.ahrq.gov) and in print through the Agency for Healthcare Research and Quality Publications Clearinghouse (800-358-9295).


Ann Intern Med. 2005;143(1):32-37. doi:10.7326/0003-4819-143-1-200507050-00008
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This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for HIV infection and the supporting scientific evidence, and updates the 1996 recommendations on this topic. The complete information on which this statement is based, including evidence tables and references, is included in the summaries of the evidence and evidence syntheses on this topic, available through the USPSTF Web site (www.preventiveservices.ahrq.gov). The recommendation is also posted on the Web site of the National Guideline Clearinghouse (www.guideline.gov).

*For a list of the members of the U.S. Preventive Services Task Force, see the Appendix.

The U.S. Preventive Services Task Force (USPSTF) strongly recommends that clinicians screen for HIV all adolescents and adults at increased risk for HIV infection (see Clinical Considerations for discussion of risk factors). This is a grade A recommendation. (See Appendix Table 1 for a description of the USPSTF classification of recommendations.)

Table Jump PlaceholderAppendix Table 1.  U.S. Preventive Services Task Force Recommendations and Ratings

The USPSTF found good evidence that both standard and U.S. Food and Drug Administration (FDA)–approved rapid screening tests accurately detect HIV infection. The USPSTF also found good evidence that appropriately timed interventions, particularly highly active antiretroviral therapy (HAART), lead to improved health outcomes for many of those screened, including reduced risk for clinical progression and reduced mortality. Since false-positive test results are rare, harms associated with HIV screening are minimal. Potential harms of true-positive test results include increased anxiety, labeling, and effects on close relationships. Most adverse events associated with HAART, including metabolic disturbances associated with an increased risk for cardiovascular events, may be ameliorated by changes in regimen or appropriate treatment. The USPSTF concluded that the benefits of screening individuals at increased risk substantially outweigh potential harms.(See Appendix Table 2 for a description of the USPSTF classification of levels of evidence.)

Table Jump PlaceholderAppendix Table 2.  U.S. Preventive Services Task Force Grades for Strength of Overall Evidence

The USPSTF makes no recommendation for or against routinely screening for HIV adolescents and adults who are not at increased risk for HIV infection (see Clinical Considerations for discussion of risk factors). This is a grade C recommendation.

The USPSTF found fair evidence that screening adolescents and adults not known to be at increased risk for HIV can detect additional individuals with HIV, and good evidence that appropriately timed interventions, especially HAART, lead to improved health outcomes for some of these individuals. However, the yield of screening persons without risk factors would be low, and potential harms associated with screening have been noted (see earlier discussion). The USPSTF concluded that the benefit of screening adolescents and adults without risk factors for HIV is too small relative to potential harms to justify a general recommendation.

The USPSTF recommends that clinicians screen all pregnant women for HIV. This is a grade A recommendation.

The USPSTF found good evidence that both standard and FDA-approved rapid screening tests accurately detect HIV infection in pregnant women and fair evidence that introduction of universal prenatal counseling and voluntary testing increases the proportion of HIV-infected women who receive a diagnosis and are treated before delivery. There is good evidence that recommended regimens of HAART are acceptable to pregnant women and lead to significantly reduced rates of mother-to-child transmission. Early detection of maternal HIV infection also allows for discussion of elective cesarean section and avoidance of breastfeeding, both of which are associated with lower HIV transmission rates. There is no evidence of an increase in fetal anomalies or other fetal harm associated with currently recommended antiretroviral regimens (with the exception of efavirenz; see following discussion). Serious or fatal maternal events are rare using currently recommended combination therapies. The USPSTF concluded that the benefits of screening all pregnant women substantially outweigh potential harms.

In 1996, the USPSTF recommended routine counseling and screening for all persons at increased risk for HIV infection (a grade A recommendation) and routine counseling and screening for high-risk pregnant women, as well as those residing in communities where the prevalence of seropositive newborns is increased (a grade A recommendation) (1). At that time, the USPSTF found insufficient evidence to recommend for or against routine HIV screening for persons without identified risk factors (a grade C recommendation) and insufficient evidence to recommend for or against universal prenatal screening in low-prevalence communities (a grade C recommendation). Testing infants born to high-risk mothers was recommended when the antibody status of the mother is unknown (a grade B recommendation). Since then, the USPSTF approach to making recommendations has changed (2) and significant new evidence on screening for and treating HIV infection has been published in the medical literature. Therefore, this recommendation statement has been updated and revised on the basis of a new review of the literature, using the current USPSTF methodology.

A person is considered at increased risk for HIV infection (and thus should be offered HIV testing) if he or she reports 1 or more individual risk factors or receives health care in a high-prevalence or high-risk clinical setting.

Individual risk for HIV infection is assessed through a careful patient history. Those at increased risk (as determined by prevalence rates) include men who have had sex with men after 1975; men and women having unprotected sex with multiple partners; past or present injection drug users; men and women who exchange sex for money or drugs or have sex partners who do; individuals whose past or present sex partners were HIV-infected, bisexual, or injection drug users; persons being treated for sexually transmitted diseases (STDs); and persons with a history of blood transfusion between 1978 and 1985. Persons who request an HIV test despite reporting no individual risk factors may also be considered at increased risk, since this group is likely to include individuals not willing to disclose high-risk behaviors.

There is good evidence of increased yield from routine HIV screening of persons who report no individual risk factors but are seen in high-risk or high-prevalence clinical settings. High-risk settings include STD clinics, correctional facilities, homeless shelters, tuberculosis clinics, clinics serving men who have sex with men, and adolescent health clinics with a high prevalence of STDs. High-prevalence settings are defined by the Centers for Disease Control and Prevention (CDC) as those known to have a 1% or greater prevalence of infection among the patient population being served. Where possible, clinicians should consider the prevalence of HIV infection or the risk characteristics of the population they serve in determining an appropriate screening strategy. Data are currently lacking to guide clinical decisions about the optimal frequency of HIV screening.

Current evidence supports the benefit of identifying and treating asymptomatic individuals in immunologically advanced stages of HIV disease (CD4 cell counts <200 cells/mm3[< 0.200 × 109 cells/L]) with HAART. Appropriate prophylaxis and immunization against certain opportunistic infections have also been shown to be effective interventions for these individuals. Use of HAART can be considered for asymptomatic individuals who are in an earlier stage of disease but are at high risk for disease progression (CD4 cell count <350 cells/mm3[< 0.350 × 109 cells/L] or viral load >100 000 copies/mL), although definitive evidence of a significant benefit of starting HAART at these counts is currently lacking.

The standard test for diagnosing HIV infection, the repeatedly reactive enzyme immunoassay followed by confirmatory Western blot or immunofluorescent assay, is highly accurate (sensitivity and specificity, ≥99%). Rapid HIV antibody testing is also highly accurate; can be performed in 10 to 30 minutes; and, when offered at the point of care, is useful for screening high-risk patients who do not receive regular medical care (for example, those seen in emergency departments), as well as women with unknown HIV status who present in active labor.

Early identification of maternal HIV seropositivity allows early antiretroviral treatment to prevent mother-to-child transmission, allows providers to avoid obstetric practices that may increase the risk for transmission, and allows an opportunity to counsel the mother against breastfeeding (also known to increase the risk for transmission). There is evidence that the adoption of “opt-out” strategies to screen pregnant women (who are informed that an HIV test will be conducted as a standard part of prenatal care unless they decline it) has resulted in higher testing rates. However, ethical and legal concerns of not obtaining specific informed consent for an HIV test using the “opt-out” strategy have been raised. While dramatic reductions in HIV transmission to neonates have been noted as a result of early prenatal detection and treatment, the extent to which detection of HIV infection and intervention during pregnancy may improve long-term maternal outcomes is unclear.

Of the estimated 850 000 to 950 000 persons in the United States infected with HIV-1, 25% are thought to be unaware of their status (34). If untreated, almost all infected individuals will eventually develop AIDS, defined by opportunistic infection or severe immune dysfunction. Despite significant recent advances in treatment, AIDS is the seventh leading cause of death in persons age 15 to 24 years and the fifth leading cause of death in persons age 25 to 44 years in the United States (5).

Incidence rates of HIV (an estimated 40 000 new infections annually) have remained steady in the United States over the past decade (6). This figure includes infection through mother-to-child (vertical) transmission, with approximately 300 infants infected each year. Women are the fastest-growing group of persons with new HIV diagnoses, and an estimated 6000 to 7000 HIV-positive women give birth each year in the United States (78). Effective interventions are available to reduce rates of vertical transmission for women diagnosed with HIV infection. However, in 2000, 40% of infected infants were born to mothers not known to have HIV infection before delivery (9).

To update its 1996 recommendations on HIV screening, the USPSTF examined the evidence from 1983 through June 2004 on the benefits and harms of screening and of currently available interventions for HIV infection in adults, adolescents, and pregnant women. Relevant studies on risk factor assessment and the accuracy and acceptability of testing were also reviewed.

The USPSTF review found that standard testing for HIV infection has a sensitivity and specificity greater than 99% and that false-positive test results are rare, even in low-risk settings (1011). While indeterminate results may occur a little more frequently among parous and pregnant women, the diagnostic accuracy of standard HIV testing is thought to be similar for pregnant women and nonpregnant women and men (12). Alternative FDA-approved screening technologies are also highly accurate and may increase testing acceptability. Compared with standard HIV testing, the reported sensitivities of rapid tests on blood specimens range from 96% to 100%, with specificities greater than 99.9% (1315). Reported sensitivities and specificities of oral fluid HIV tests are also high (>99%), although the diagnostic accuracy of urine tests appears lower than that of standard testing (1617). One good-quality study of the only FDA-approved home collection kit, which uses fingerstick blood spot samples, found it to be highly accurate compared with standard testing (18).

A large, good-quality U.S. study found that risk factor assessment can identify individuals at substantially higher risk for HIV but still misses a significant proportion (20% to 26%) of HIV-positive clients who report no risk factors (19)(since some patients may choose not to disclose high-risk behaviors and others, especially women, may be unknowingly at risk from an infected sex partner) (20). There is fair evidence to indicate that a broader strategy targeted to individuals who report risk factors, combined with routine (voluntary) testing of those being seen in high-prevalence clinical settings, would result in substantially fewer missed diagnoses (2123). In 2 good-quality studies, HIV screening of populations with a 1% prevalence rate was found to be cost-effective (in terms of acceptable cost per quality-adjusted life-year) compared with no screening (2425). One study (25) found that screening populations with even lower prevalence rates is also cost-effective if one assumes secondary transmission benefits. Neither study, however, reported on the incremental cost-effectiveness of screening lower-risk versus higher-risk patients.

The wide adoption in 1995 to 1997 of the use of HAART regimens with 3 or more antiretroviral agents has been associated with a marked decline in morbidity and mortality of HIV-infected patients in the United States (3). Good-quality evidence has shown HAART regimens to be consistently effective in reducing clinical progression and mortality in persons with CD4 cell counts less than 200 cells/mm3(<0.200 × 109 cells/L) (2627); the percentage of patients found in studies to be candidates for HAART regimens at the time of HIV diagnosis has ranged from 12% to 43% (20, 28). In addition, 2 good-quality systematic reviews found that the use of antibiotic medication to prevent opportunistic infections (for example, Pneumocystis carinii pneumonia and disseminated Mycobacterium avium–intracellulare complex) is effective in persons with advanced disease (2930). Theoretically, asymptomatic patients in an earlier stage of disease at the time of diagnosis (CD4 cell counts between 200 to 350 cells/mm3[0.200 to 0.350 × 109 cells/L] or viral load >100 000 copies/mL) may also benefit from HAART regimens. However, there are no completed trials showing clinical benefit from treatment versus no treatment in such patients. Data from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial, which focuses on this group, will not be available for a few more years.

The standard of care in the United States for preventing vertical HIV transmission in seropositive pregnant women has evolved from monotherapy (zidovudine) to combination antiretroviral regimens, including HAART regimens, starting at 14 to 34 weeks' gestation through labor and augmented with 6 weeks of neonatal prophylaxis with zidovudine (31). Avoidance of breastfeeding is recommended for seropositive women since observational studies have shown that breastfeeding increases transmission rates even when adjusted for other factors, including antiretroviral use. A good-quality randomized clinical trial has demonstrated that elective cesarean section also reduces vertical transmission, compared with other modes of delivery, by minimizing contact between the fetus and infected maternal body fluids (32), although the benefit appears small in women with undetectable viral loads. There is fair to good evidence that the newer regimens, in combination with formula feeding and elective cesarean delivery, are associated with reductions in perinatal transmission ranging from 14% to 25% without interventions to 1% to 2% with interventions.

Information about the consequences of false-positive HIV test results (for example, anxiety and labeling) is mostly anecdotal, although true-positive HIV test results have been shown to result in anxiety, depression, social stigmatization, changes in relationships with sexual partners, and discrimination (33). Evidence suggests that persons testing positive for HIV (especially heterosexual serodiscordant couples) are more likely than others to avoid risky sexual behavior. On the other hand, optimistic beliefs about the effectiveness of HAART regimens have been shown to be associated with increased risky behaviors in individuals known to be seropositive (3435). All antiretroviral drugs and drug combinations are associated with specific harm profiles, although most harms are short term or self-limited and effective alternatives can often be found (36). Metabolic disturbances (hyperlipidemia and diabetes) related to HAART regimens have been associated with an increased incidence of cardiovascular events, especially with longer exposure (37). The estimated 3-year benefits of HAART regimens appear, however, to greatly outweigh the cardiovascular complications.

No significant increases in the rates of congenital anomalies, neonatal conditions, or other fetal harm have been associated with in utero exposure to FDA-approved regimens of antiretroviral drugs (38), with the exception of those including efavirenz. Efavirenz has recently been reclassified as Class D in pregnancy (positive evidence of human fetal risk). Although studies have demonstrated no ill effects of limited exposure to zidovudine monotherapy in women followed postpartum for as long as 6 years, no studies have evaluated the effects of limited exposure to combination antiretroviral drugs during pregnancy on the long-term clinical outcomes of HIV-infected women.

Counseling and HIV testing of high-risk individuals (as defined in the Clinical Considerations section) are recommended by the CDC (39), the Canadian Task Force on the Periodic Health Examination (now the Canadian Task Force on Preventive Health Care) (40), and numerous professional organizations, including the American Medical Association (AMA) (41), the American Academy of Family Physicians (AAFP) (42), the American College of Obstetricians and Gynecologists (ACOG) (43), the American College of Physicians (ACP) (44), and the Infectious Diseases Society of America (IDSA) (45). Also, the American Academy of Pediatrics (AAP) (46) considers all sexually active adolescents to be a high-risk group and recommends they be counseled and offered HIV testing. In addition, the CDC recommends that routine, voluntary testing be offered to all patients seen either in health care facilities where the prevalence of HIV infection is 1% or greater or in settings serving client populations at increased behavioral or clinical HIV risk.

The CDC, AMA, AAFP, ACOG, IDSA, AAP (47), and the American College of Nurse-Midwives (48) recommend that all pregnant women be routinely counseled and encouraged to have HIV testing. The ACOG, AAP, and the CDC go further in recommending that HIV testing be part of a routine battery of prenatal blood tests unless declined (that is, an “opt-out” approach). The CDC and ACOG also recommend retesting in the third trimester women who are known to be at high risk for HIV, as well as rapid HIV testing in labor for women with undocumented HIV status.

Appendix

Members of the U.S. Preventive Services Task Force are Alfred O. Berg, MD, MPH, Chair(University of Washington, Seattle, Washington); Janet D. Allan, PhD, RN, CS, Vice-Chair(University of Maryland, Baltimore, Baltimore, Maryland); Ned Calonge, MD, MPH (Colorado Department of Public Health and Environment, Denver, Colorado); Paul S. Frame, MD (Tri-County Family Medicine, Cohocton, and University of Rochester, Rochester, New York); Joxel Garcia, MD, MBA (Pan American Health Organization, Washington, DC); Leon Gordis, MD, MPH, DrPH (Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland); Russell Harris, MD, MPH (University of North Carolina School of Medicine, Chapel Hill, North Carolina); Mark S. Johnson, MD, MPH (University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey); Jonathan D. Klein, MD, MPH (University of Rochester School of Medicine, Rochester, New York); Carol Loveland-Cherry, PhD, RN (University of Michigan School of Nursing, Ann Arbor, Michigan); Virginia A. Moyer, MD, MPH (University of Texas Health Science Center, Houston, Texas); Judith K. Ockene, PhD (University of Massachusetts Medical School, Worcester, Massachusetts); C. Tracy Orleans, PhD (The Robert Wood Johnson Foundation, Princeton, New Jersey); Albert L. Siu, MD, MSPH (Mount Sinai Medical Center, New York, New York); Steven M. Teutsch, MD, MPH (Merck & Co., Inc., West Point, Pennsylvania); and Carolyn Westhoff, MD, MSc (Columbia University, New York, New York).

This list includes members of the Task Force at the time these recommendations were finalized. For a list of current Task Force members, go to http://www.ahrq.gov/clinic/uspstfab.htm.

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.  Revised guidelines for HIV counseling, testing, and referral and revised recommendations for HIV screening of pregnant women. MMWR Morb Mortal Wkly Rep. 2001; 50: (19) 1-86.
 
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Figures

Tables

Table Jump PlaceholderAppendix Table 1.  U.S. Preventive Services Task Force Recommendations and Ratings
Table Jump PlaceholderAppendix Table 2.  U.S. Preventive Services Task Force Grades for Strength of Overall Evidence

References

U.S. Preventive Services Task Force.  Guide to Clinical Preventive Services. 2nd ed. Washington, DC: Office of Disease Prevention and Health Promotion; 1996.
 
Harris RP, Helfand M, Woolf SH, Lohr KN, Mulrow CD, Teutsch SM. et al.  Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med. 2001; 20:21-35. PubMed
CrossRef
 
Centers for Disease Control and Prevention.  Cases of HIV Infection and AIDS in the United States, 2002. HIV/AIDS Surveillance Report, Vol. 14. Accessed athttp://www.cdc.gov/hiv/stats/hasr1402.htmon 23 March 2005.
 
Fleming P, Byers RH, Sweeney PA, Daniels D, Karon JM, Janssen RS.  HIV prevalence in the United States, 2000. In: Program and Abstracts of the 9th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, 24-28 February 2002. Alexandria, VA: Foundation for Retrovirology and Human Health; 2002.
 
Kochanek KD, Smith BL.  Deaths: Preliminary Data for 2002. National Vital Statistics Reports. vol 52, no. 13. Hyattsville, MD: National Center for Health Statistics; 2004.
 
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Celum CL, Coombs RW, Jones M, Murphy V, Fisher L, Grant C. et al.  Risk factors for repeatedly reactive HIV-1 EIA and indeterminate western blots. A population-based case-control study. Arch Intern Med. 1994; 154:1129-37. PubMed
 
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Gallo D, George JR, Fitchen JH, Goldstein AS, Hindahl MS.  Evaluation of a system using oral mucosal transudate for HIV-1 antibody screening and confirmatory testing. OraSure HIV Clinical Trials Group. JAMA. 1997; 277:254-8. PubMed
 
Martinez PM, Torres AR, Ortiz de Lejarazu R, Montoya A, Martin JF, Eiros JM.  Human immunodeficiency virus antibody testing by enzyme-linked fluorescent and western blot assays using serum, gingival-crevicular transudate, and urine samples. J Clin Microbiol. 1999; 37:1100-6. PubMed
 
Frank AP, Wandell MG, Headings MD, Conant MA, Woody GE, Michel C.  Anonymous HIV testing using home collection and telemedicine counseling. A multicenter evaluation. Arch Intern Med. 1997; 157:309-14. PubMed
 
Peterman TA, Todd KA, Mupanduki I.  Opportunities for targeting publicly funded human immunodeficiency virus counseling and testing. J Acquir Immune Defic Syndr Hum Retrovirol. 1996; 12:69-74. PubMed
 
Klein D, Hurley LB, Merrill D, Quesenberry CP Jr.  Review of medical encounters in the 5 years before a diagnosis of HIV-1 infection: implications for early detection. J Acquir Immune Defic Syndr. 2003; 32:143-52. PubMed
 
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HIV Infection; Ignorance Is Not Bliss
Posted on July 13, 2005
Curt G. Beckwith
Brown Medical School, Division of Infectious Diseases
Conflict of Interest: None Declared

The U.S. Preventive Services Task Force (USPSTF) recently published updated guidelines for HIV screening [1]. In preparing these guidelines, the USPSTF reviewed studies that demonstrated how routinely offering HIV testing, as opposed to offering testing only when HIV risk is identified, increases the number of persons diagnosed with HIV and is cost-effective [2-4]. Despite this, the USPSTF, along with the CDC, ACP, Infectious Disease Society of America and other healthcare organizations, have failed to expand recommendations for routine testing. The updated USPSTF guidelines, similar to guidelines published over the past decade, recommend routine testing only for persons identified as high-risk; for those residing in areas with increased HIV prevalence (greater than or equal to 1%); and for all pregnant women. Unfortunately, this strategy has failed to decrease the proportion of persons infected with undiagnosed HIV in this country and this is unlikely to change as a result of these revised guidelines.

Experience has revealed that testing strategies that depend on risk assessment are inadequate. Twenty to twenty-six percent of HIV-positive patients report "no risk factors"[5]. Risk assessment is inherently inaccurate as healthcare providers may be reluctant or uncomfortable obtaining detailed risk histories and patients may not divulge risk behavior. Screening pregnant women for HIV, which is not based on risk, has led to dramatic decreases in vertical transmission of HIV infection. Why can't we learn from our successes and expand routine testing to all persons?

The benefits of expanding routine HIV testing are unmistakable. Knowledge of infection provides an opportunity to prevent others from being infected, to initiate of highly effective therapy, and to prevent opportunistic infections. The potential harm associated with HIV screening is minimal. The HIV testing algorithm is highly accurate and inexpensive. Concerns about potential harm associated with routine testing, as discussed in the USPSTF guidelines, revolve mostly around the psychosocial consequences associated with true-positive results. These are important factors requiring attention when caring for newly diagnosed patients. However, fear of these possible consequences is not an acceptable reason to withhold testing.

Routine "opt-out" testing strategies with simple consent procedures, in settings other than the pre-natal arena, are urgently needed. Routinely offering HIV testing in primary care, inpatient, urgent care and emergency departments will decrease stigma and anxiety associated with HIV testing and will lead to more persons being diagnosed. We cannot allow ineffective HIV testing policies to be perpetuated when experience demonstrates that change is required.

References: 1. U.S. Preventive Services Task Force. Screening for HIV: Recommendation Statement. Ann Intern Med. 2005; 143: 32-37. 2. Voluntary HIV testing as part of routine medical care¡ªMassachusetts, 2002. MMWR Morb Mortal Wkly Rep. 2004;53:523-6. 3. Routinely recommended HIV testing at an urban urgent-care clinic¡ªAtlanta, Georgia, 2000. MMWR Morb Mortal Wkly Rep. 2001;50:538-41. 4. Paltiel AD, Weinstein MC, Kimmel AD, Seage GR 3rd, Losina E, Zhang H, et al. Expanded screening for HIV in the United States¡ªan analysis of cost-effectiveness. N Engl J Med. 2005;352:586-95. 5. Peterman TA, Todd KA, Mupanduki I. Opportunities for targeting publicly funded human immunodeficiency virus counseling and testing. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;12:69-74.

Conflict of Interest:

None declared

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Summary for Patients

Screening for HIV: U.S. Preventive Services Task Force Recommendations

The summary below is from the full reports titled “Screening for HIV: Recommendation Statement,” “Prenatal Screening for HIV: A Review of the Evidence for the U.S. Preventive Services Task Force,” and “Screening for HIV: A Review of the Evidence for the U.S. Preventive Services Task Force.” They are in the 5 July 2005 issue of Annals of Internal Medicine (volume 143, pages 32-37, 38-54, and 55-73). The first report was written by the U.S. Preventive Services Task Force; the second and third reports were written by R. Chou, A.K. Smits, L.H. Huffman, R. Fu, and P.T. Korthuis.

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