Forty-one of the 44 drugs studied were less expensive at Canadian pharmacies than at American pharmacies. All 3 drugs that were more expensive in Canada were drugs for erectile dysfunction (impotence). The researchers estimated that Americans can save approximately 24% if they purchase their prescription drugs from Canada. The drugs that had the largest yearly savings were Zyprexa (olanzapine, Eli Lilly, Indianapolis, Indiana; $1159 U.S. savings per year), Actos (pioglitazone, Eli Lilly; $853 U.S. savings per year), and Nexium (esomeprazole, AstraZeneca, Wilmington, Delaware; $772 U.S. savings per year). The researchers did not include shipping fees. The maximum shipping fees were $60 U.S. per year.