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Estimated Risks for Developing Obesity in the Framingham Heart Study

Ramachandran S. Vasan, MD; Michael J. Pencina, PhD; Mark Cobain, PhD; Matthew S. Freiberg, MD; and Ralph B. D'Agostino, PhD
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From the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, and Boston University, Boston, Massachusetts; and Unilever Research, Colworth, Bedfordshire, United Kingdom.


Grant Support: In part by the National Institutes of Health and National Heart, Lung, and Blood Institute contract N01-HC-38038. Dr. Vasan was partly supported by National Institutes of Health and National Heart, Lung, and Blood Institute grant 2K24 HL 04334.

Potential Financial Conflicts of Interest: Employment: M. Cobain (Unilever).

Requests for Single Reprints: Ramachandran S. Vasan, MD, The Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702-5803; e-mail, vasan@bu.edu.

Current Author Addresses: Dr. Vasan: The Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702-5803.

Drs. Pencina and D'Agostino: Boston University, 111 Cummington Street, Boston, MA 02135.

Dr. Cobain: Unilever Research, Colworth House, Sharnbrook, Bedforshire MK44 1LQ, United Kingdom.

Dr. Freiberg: University of Pittsburgh and Epidemiology Center for Research on Health Care, 230 McKee Place, Suite 600, Pittsburgh, PA 15213.

Author Contributions: Conception and design: R.S. Vasan, M.J. Pencina, R.B. D'Agostino.

Analysis and interpretation of the data: R.S. Vasan, M.J. Pencina, M. Cobain, M.S. Freiberg, R.B. D'Agostino.

Drafting of the article: R.S. Vasan, M.J. Pencina, M.S. Freiberg.

Critical revision of the article for important intellectual content: R.S. Vasan, M.J. Pencina, M. Cobain, M.S. Freiberg, R.B. D'Agostino.

Final approval of the article: R.S. Vasan, M.J. Pencina, M. Cobain, M.S. Freiberg, R.B. D'Agostino.

Statistical expertise: M.J. Pencina, R.B. D'Agostino.

Obtaining of funding: R.S. Vasan, R.B. D'Agostino.

Collection and assembly of data: R.B. D'Agostino.


Ann Intern Med. 2005;143(7):473-480. doi:10.7326/0003-4819-143-7-200510040-00005
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The design and selection criteria of the Framingham Offspring Study have been described previously (15). Participants in the study are examined approximately every 4 years. Individuals (men and nonpregnant women) were eligible for our investigation if they attended at least 2 routine examinations between 1971 and 2001 and were not underweight (BMI < 18.5 kg/m2). At each routine Framingham Offspring Study examination, investigators used a standardized protocol to measure height (to the nearest 0.25 inch) and weight (to the nearest pound) (1617). Investigators calculated BMI as the weight (kg) divided by height squared (m2). All participants gave written informed consent, and the institutional review board of the Boston Medical Center approved the study protocol.

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obesity ; overweight

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Figure.
Mortality-adjusted cumulative incidence rates of obesity for women (top) and men (bottom) for different age groups.

Data are for people free of obesity at baseline.

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Summary for Patients

Short- and Long-Term Risks for Middle-Aged Adults Becoming Overweight or Obese

The summary below is from the full report titled “Estimated Risks for Developing Obesity in the Framingham Heart Study.” It is in the 4 October 2005 issue of Annals of Internal Medicine (volume 143, pages 473-480). The authors are R.S. Vasan, M.J. Pencina, M. Cobain, M.S. Freiberg, and R.B. D'Agostino.

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