0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Antineutrophil Cytoplasmic Antibodies and the Churg–Strauss Syndrome

Régis Sablé-Fourtassou, MD; Pascal Cohen, MD; Alfred Mahr, MD; Christian Pagnoux, MD; Luc Mouthon, MD, PhD; David Jayne, MD; Daniel Blockmans, MD, PhD; Jean-François Cordier, MD; Philippe Delaval, MD; Xavier Puechal, MD, PhD; Dominique Lauque, MD; Jean-François Viallard, MD, PhD; Abdelkader Zoulim, MD; Loïc Guillevin, MD, the French Vasculitis Study Group*
[+] Article and Author Information

From Hôpital Cochin, Assistance Publique–Hôpitaux de Paris, Université Paris 5–René Descartes, Paris, France; Addenbrooks Hospital, Cambridge, United Kingdom; University Hospital Gasthuisberg, Leuven, Belgium; Hôpital Louis Pradel, Hospices Civils de Lyon, France; Hôpital Pontchaillou, Rennes, France; Centre Hospitalier, Le Mans, France; Hôpital Purpan, Toulouse, France; Hôpital Haut-Lévêque, Bordeaux, France; and Centre Hospitalier de la Côte de Nacre, Caen, France.


Grant Support: This work was funded by grants from the Ministère de la Recherche (UPRES 3409) and the Institut National de la Recherche Médicale (INSERM, GIS Maladies Rares). Patients were recruited with the help of the Hospices Civils de Lyon, which sponsored the therapeutic trials, the Assistance Publique–Hôpitaux de Paris, and the members of the French Vasculitis Study Group and the European Vasculitis Study Group (EUVAS).

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Loïc Guillevin, MD, Department of Internal Medicine, Hôpital Cochin, Université Paris 5–René Descartes, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France; e-mail, loic.guillevin@cch.ap-hop-paris.fr.

Current Author Addresses: Dr. Sablé-Fourtassou: Department of Internal Medicine, Hôpital Avicenne, Université Paris 13, 125, rue de Stalingrad, 93009 Bobigny, France.

Drs. Cohen, Mahr, Pagnoux, Mouthon, and Guillevin: Department of Internal Medicine, Hôpital Cochin, Université Paris 5–René Descartes, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.

Dr. Jayne: Department of Nephrology and Vasculitis, Renal Unit, Box 118, Addenbrookes Hospital, Cambridge CB2 2QQ, United Kingdom.

Dr. Blockmans: University Hospital Gasthuisberg, Dienst Interne Geneeskunde, Herestraat 49, B-3000 Leuven, Belgium.

Dr. Cordier: Department of Respiratory Medicine, Reference Center for Orphan Pulmonary Diseases, Hôpital Louis Pradel, Université Claude Bernard, 69677 Lyon (Bron), France.

Dr. Delaval: Department of Pneumologie, Hôpital Pontchaillou, rue Henri Le Guillou, 35033, Rennes, France.

Dr. Puechal: Department of Rheumatology, Centre Hospitalier Le Mans, 194, avenue Rubillard, 72037 Le Mans Cedex 9, France.

Dr. Lauque: Department of Internal Medicine and Pneumology, Hôpital Purpan, University of Toulouse, Place du Dr Baylac, 31059 Toulouse, Cedex, France.

Dr. Viallard: Department of Internal Medicine and Infectious Diseases, Hôpital du Haut-Lévêque, avenue de Magellan, 33604 Pessac, Cedex, France.

Dr. Zoulim: Department of Internal Mecicine, CHU Côte de Nacre, 14000 Caen, France.

Author Contributions: Conception and design: P. Cohen, D. Jayne, J.-F. Cordier, X. Puechal, L. Guillevin.

Analysis and interpretation of the data: R. Sablé-Fourtassou, P. Cohen, A. Mahr, C. Pagnoux, L. Mouthon, L. Guillevin.

Drafting of the article: R. Sablé-Fourtassou, A. Mahr, C. Pagnoux, L. Mouthon, L. Guillevin.

Critical revision of the article for important intellectual content: R. Sablé-Fourtassou, C. Pagnoux, L. Mouthon, D. Jayne, D. Blockmans, J.-F. Cordier, X. Puechal, L. Guillevin.

Final approval of the article: R. Sablé-Fourtassou, P. Cohen, A. Mahr, C. Pagnoux, L. Mouthon, D. Jayne, D. Blockmans, J.-F. Cordier, X. Puechal, D. Lauque, L. Guillevin.

Provision of study materials or patients: P. Cohen, C. Pagnoux, D. Jayne, D. Blockmans, J.-F. Cordier, P. Delaval, X. Puechal, D. Lauque, F. Viallard, A. Zoulim, L. Guillevin.

Statistical expertise: A. Mahr.

Obtaining of funding: L. Guillevin.

Administrative, technical, or logistic support: D. Jayne, L. Guillevin.

Collection and assembly of data: P. Cohen, C. Pagnoux, D. Jayne,


Ann Intern Med. 2005;143(9):632-638. doi:10.7326/0003-4819-143-9-200511010-00006
Text Size: A A A

We believe that our study is the first to report the results of a prospective multicenter study that compared patients with the Churg–Strauss syndrome as a function of their ANCA status at diagnosis. The strengths of our study include the homogeneous management (that is, we included patients within a limited period of time, investigated them in the same manner, and recorded their data prospectively) and the large number of centers and medical specialties that participated in patient recruitment, which is representative of the Churg–Strauss syndrome in its different clinical aspects.

First Page Preview

View Large
First page PDF preview

Figures

Grahic Jump Location
Figure.
Study flow chart.

The flow chart shows clinical status of patients with the Churg–Strauss syndrome as a function of their antineutrophil cytoplasmic antibody (ANCA) positivity or negativity. One hundred one patients (37 ANCA-positive, 64 ANCA-negative) were alive at last update.

Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)