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The Relationship between Condom Use and Herpes Simplex Virus Acquisition

Anna Wald, MD, MPH; Andria G.M. Langenberg, MD; Elizabeth Krantz, MS; John M. Douglas Jr, MD; H. Hunter Handsfield, MD; Richard P. DiCarlo, MD; Adaora A. Adimora, MD, MPH; Allen E. Izu, MD; Rhoda Ashley Morrow, PhD; and Lawrence Corey, MD
[+] Article, Author, and Disclosure Information

From University of Washington, Seattle, Washington; Chiron Corporation, Emeryville, California; Denver Department of Public Health, Denver, Colorado; Louisiana State University School of Medicine, New Orleans, Louisiana; University of North Carolina School of Medicine, Chapel Hill, North Carolina; and Fred Hutchinson Cancer Research Center, Seattle, Washington.

Note: This paper was presented in part at the 2002 National STD Prevention Conference, San Diego, California, 4–7 March 2002.

Grant Support: In part by National Institutes of Health Herpes Program Project Grant AI-30731 and Centers for Disease Control and Prevention Prevention Research Initiative UR6/CCU017828-02.

Potential Financial Conflicts of Interest: Employment: A.G.M. Langenberg (Chiron Corp., Corgentech, Inc.), A.E. Izu (Chiron Corp.); Stock ownership or options (other than mutual funds): A.G.M. Langenberg (Chiron Corp.), A.E. Izu (Chiron Corp.); Grants received: R.A. Morrow (Chiron Corp.), L. Corey (Chiron Corp.).

Requests for Single Reprints: Anna Wald, MD, MPH, University of Washington, Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122; e-mail, annawald@u.washington.edu.

Current Author Addresses: Dr. Wald and Ms. Krantz: University of Washington, Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122.

Dr. Langenberg: Corgentec, Inc., 650 Gateway Boulevard, South San Francisco, CA 94080.

Dr. Douglas: Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333.

Dr. Handsfield: University of Washington, 325 Ninth Avenue, Seattle, WA 98104.

Dr. DiCarlo: Louisiana University School of Medicine, 2020 Gravier Street, Suite 102, New Orleans, LA 70012.

Dr. Adimora: Division of Infectious Disease, University of North Carolina School of Medicine, CB 7030, Chapel Hill, NC 27599.

Dr. Izu: Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608.

Dr. Morrow: University of Washington, Box 359300-W8814, Seattle, WA 98195.

Dr. Corey: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109.

Author Contributions: Conception and design: A. Wald, A.G.M. Langenberg, A.E. Izu, L. Corey.

Analysis and interpretation of the data: A. Wald, E. Krantz, A.E. Izu, L. Corey.

Drafting of the article: A. Wald, E. Krantz.

Critical revision of the article for important intellectual content: A. Wald, A.G.M. Langenberg, J.M. Douglas Jr, R.P. DiCarlo, R.A. Morrow, L. Corey.

Final approval of the article: A. Wald, A.G.M. Langenberg, E. Krantz, J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora, A.E. Izu, R.A. Morrow, L. Corey.

Provision of study materials or patients: J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora.

Statistical expertise: E. Krantz.

Obtaining of funding: A. Wald, L. Corey.

Administrative, technical, or logistical support: A. Wald, R.A. Morrow, L. Corey.

Collection and assembly of data: A.G.M. Langenberg, J.M. Douglas Jr., H.H. Handsfield, R.P. DiCarlo, A.A. Adimora, A.E. Izu, R.A. Morrow.

Ann Intern Med. 2005;143(10):707-713. doi:10.7326/0003-4819-143-10-200511150-00007
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Of the 1862 participants who enrolled for the vaccine trial, 19 did not report any sexual activity during the entire study and thus were excluded from this analysis. The remaining 1843 participants included 1365 men and 478 women. The median age of the participants was 27 years. Sixty-two percent were white, 32% were African American, and 6% were people of other races; 1184 participants (64%) were seropositive for HSV-1 at study entry. Most men and women qualified for the study by reporting 4 or more partners in the past year (66% of men, 70% of women); some reported 1 or more sexually transmitted diseases in the past year (12% of men, 19% of women); and the remainder met both criteria (22% of men, 11% of women).

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Grahic Jump Location
Frequency of herpes simplex virus (HSV)-2 acquisition in each study interval stratified by condom use.

Solid circles represent the HSV-2 incidence rate per 100 person-years, and bars represent 95% CIs for these rates.

Grahic Jump Location




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Summary for Patients

Condom Use and Genital Herpes

The summary below is from the full report titled “The Relationship between Condom Use and Herpes Simplex Virus Acquisition.” It is in the 15 November 2005 issue of Annals of Internal Medicine (volume 143, pages 707-713). The authors are A. Wald, A.G.M. Langenberg, E. Krantz, J.M. Douglas, H.H. Handsfield, R.P. DiCarlo, A.A. Adimora, A.E. Izu, R.A. Morrow, and L. Corey.


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