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Improving Helicobacter pylori Eradication Regimens

Fritz Francois, MD; and Martin J. Blaser, MD
[+] Article, Author, and Disclosure Information

From New York University School of Medicine, New York, NY 10010.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Fritz Francois, MD, Division of Gastroenterology, New York University School of Medicine, 423 East 23rd Street, Room 11132N, New York, NY 10010; e-mail, fritz.francois@med.nyu.edu.

Current Author Addresses: Dr. Francois: Division of Gastroenterology, New York University School of Medicine, 423 East 23rd Street, Room 11132N, New York, NY 10010.

Dr. Blaser: New York University School of Medicine, Old Bellevue 6 A606, 550 First Avenue, New York, NY 10016.

Ann Intern Med. 2006;144(2):140-141. doi:10.7326/0003-4819-144-2-200601170-00013
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Helicobacter pylori colonization has known costs to humans, including increased risk for peptic ulcer disease (1), gastric adenocarcinoma (2), and gastric lymphoma (3). The finding that elimination of H. pylori changes the natural history of peptic ulcer disease (4) and gastric mucosa–associated lymphoid tissue lymphoma (5) has led to the development of successful strategies to clear the organism from persons with these disorders. Over the past 20 years, regimens that use acid-suppressing agents in conjunction with several antibiotics (in particular, clarithromycin [6]) have been highly successful for H. pylori eradication (7). However, recent reports detail decreasing efficacy of these combination therapies (8). Why is this happening, and what can be done to improve therapies to eradicate H. pylori?

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