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Inhaled Treprostinil for Treatment of Chronic Pulmonary Arterial Hypertension

Robert Voswinckel, MD; Hossein A. Ghofrani, MD; Friedrich Grimminger, MD; Werner Seeger, MD; and Horst Olschewski, MD
[+] Article and Author Information

From the University of Giessen Lung Center, 35392 Giessen, Germany, and Medical University Graz, 8036 Graz, Austria.


Potential Financial Conflicts of Interest: Consultancies: H.A. Ghofrani (LungRX), W. Seeger (LungRX), H. Olschewski (LungRX); Honoraria: H.A. Ghofrani (LungRX); Grants received: W. Seeger (LungRX).


Ann Intern Med. 2006;144(2):149-150. doi:10.7326/0003-4819-144-2-200601170-00026
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Figure.
Acute hemodynamic response of a patient with idiopathic pulmonary arterial hypertension to the inhalation of nitric oxide (20 parts per million) and 15 µg of treprostinil.top, squarestop, circlesbottom, squaresbottom, circles

Asterisks indicate administration of nitric oxide, and daggers indicate administration of treprostinil. Pulmonary artery pressure was substantially reduced with nitric oxide and even further reduced with treprostinil ( ). Systemic arterial pressure was not affected by either substance ( ). Pulmonary vascular resistance was substantially reduced with nitric oxide and even further reduced with treprostinil; the effect of treprostinil outlasted the observation time of 180 minutes ( ). Long-lasting improvement of mixed venous oxygen saturation represented improved cardiac output in absence of gas exchange deterioration ( ).

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