0
Summaries for Patients |

Twenty-Four Cases of Pneumonitis in Kidney Transplantation Recipients Receiving Sirolimus FREE

[+] Article and Author Information

The summary below is from the full report titled “Brief Communication: Sirolimus-Associated Pneumonitis: 24 Cases in Renal Transplant Recipients.” It is in the 4 April 2006 issue of Annals of InternalMedicine (volume 144, pages 505-509). The authors are L. Champion, M. Stern, D. Israël-Biet, M.-F. Mamzer-Bruneel, M.-N. Peraldi, H. Kreis, R. Porcher, and E. Morelon.


Ann Intern Med. 2006;144(7):I-45. doi:10.7326/0003-4819-144-7-200604040-00004
Text Size: A A A

What is the problem and what is known about it so far?

Kidney transplantation involves surgically implanting a donated kidney into a patient whose own kidneys have stopped working. Because the body will develop an immune reaction to foreign tissues such as a donated kidney, it is necessary to treat patients with kidney transplants with drugs to suppress their immune systems. One such drug is sirolimus. There have been previous reports of a lung condition called pneumonitis in kidney transplant recipients who took sirolimus. However, there is limited information about this potential complication. Pneumonitis is a condition involving inflammation in the lungs that interferes with normal lung function.

Why did the researchers do this particular study?

To provide more detailed information about pneumonitis in kidney transplant recipients who received sirolimus than was included in previous reports of this condition.

Who was studied?

24 patients from 1 French transplantation center who developed pneumonitis while taking sirolimus after kidney transplantation.

How was the study done?

The researchers reviewed the medical records of the 24 patients and described the symptoms, laboratory tests, and outcomes.

What did the researchers find?

Common symptoms included cough in 23 patients, fatigue in 20 patients, fever in 16 patients, and shortness of breath in 8 patients. Computed tomography scans of the chest and a test called bronchoalveolar lavage were helpful in making the diagnosis in these patients. Bronchoalveolar lavage involves inserting a special instrument down the throat and into the lungs to obtain samples for examination. All patients required discontinuation of sirolimus therapy before they improved, and all recovered completely within 6 months of withdrawal of the drug.

What were the limitations of the study?

This description of 24 patients from 1 center does not provide information about how frequently this complication occurs.

What are the implications of the study?

Computed tomography and bronchoalveolar lavage seem to be helpful in making a diagnosis of sirolimus-associated pneumonitis. Patients seem to recover within 6 months of discontinuing sirolimus therapy.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)