Atherosclerosis is a disease process in which plaques develop on the inside walls of arteries, the blood vessels that transport blood containing oxygen to the body. Coronary atherosclerosis refers to the presence of these plaques in the arteries that supply blood to the heart muscle. People can have coronary artery plaques but have no symptoms of cardiovascular disease (subclinical coronary atherosclerosis). When these plaques become large or rupture, they can block off blood flow through the artery. When this occurs in the coronary arteries, the arteries that supply blood to heart muscle, a heart attack can result. Previous studies have shown a link between coronary artery disease events, such as heart attack, and psychosocial factors, such as stress, anxiety, depression, and anger. It is not known whether this link is because psychosocial factors can trigger the development of atherosclerosis or because these factors trigger the events in people who already have atherosclerosis. If people with high levels of stress, anxiety, depression, or anger are more likely to have subclinical coronary atherosclerosis than those with low levels of these psychosocial factors, this would suggest that the psychosocial factors play a role in the development of the disease rather than just triggering events once the disease is already present.