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Abatacept in Rheumatoid Arthritis: A New Branch on the “Biologics” Tree

Maarten Boers, MSc, MD, PhD
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From VU University Medical Center, Amsterdam, the Netherlands.

Potential Financial Conflicts of Interest: Consultancies: Bristol-Myers Squibb, GlaxoSmithKline, Novartis, Genentech/Roche, Nitec Pharma, Johnson & Johnson, Wyeth, Shionogi, Pfizer, Savient; Grants received: OMERACT.

Current Author Address: Maarten Boers, MSc, MD, PhD, Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands.

Ann Intern Med. 2006;144(12):933-935. doi:10.7326/0003-4819-144-12-200606200-00012
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In the last 2 decades, rheumatology has become a field with high yield potential for drug developers, and the complex diseases that rheumatologists treat have come under intense scrutiny. Targeting tumor necrosis factor (TNF) and its receptor by monoclonal antibodies has become a highly successful treatment for rheumatoid arthritis (RA) and a growing list of other diseases. Ongoing research is increasing both our knowledge of (patho)immunology and our treatment options. Once the dust has settled, science historians will doubtless find many research opportunities in the almost yearly change of paradigms of autoimmune disease.

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