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Do Statins Protect the Kidney by Reducing Proteinuria?

Marcello Tonelli, MD, SM
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From University of Alberta and Institute of Health Economics, Edmonton, Alberta T6G 2G3, Canada.

Acknowledgments: The author thanks Drs. Barbara Ballermann and Neesh Pannu for their helpful suggestions.

Grant Support: Dr. Tonelli was supported by salary awards from the Canadian Institutes of Health Research and the Alberta Heritage Foundation for Medical Research.

Potential Financial Conflicts of Interest: Dr. Tonelli received a research grant (>$10 000) from Bristol-Myers Squibb in 2003, served on a Pfizer advisory board in 2004, received honoraria (<$10 000) from Pfizer for continuing medical education lectures in 2004–2005, and received a research grant from AstraZeneca (<$10 000) in 2005. Honoraria (<$10 000) provided by Merck and AstraZeneca for academic grand rounds given in 2006 were paid directly to charity.

Corresponding Author: Marcello Tonelli, MD, SM, 7-129 Clinical Sciences Building, 8440-112 Street, Edmonton, Alberta T6G 2G3, Canada.

Ann Intern Med. 2006;145(2):147-149. doi:10.7326/0003-4819-145-2-200607180-00015
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The first time someone proposed that dyslipidemia caused progressive kidney disease was more than a century ago (1). The proposal has support from experimental and clinical evidence (2), and some have suggested that lipid-modifying medication may reduce proteinuria and prevent kidney function loss. This editorial focuses on statins, which have been the most extensively studied class of lipid-lowering drug.

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