The full content of Annals is available to subscribers

Subscribe/Learn More  >
Current Clinical Issues |

Alterations in Processes and Priorities Needed for New Drug Development

Jennifer Fisher Wilson
[+] Article, Author, and Disclosure Information

Science Reporter, Annals of Internal Medicine

Potential Financial Conflicts of Interest: None disclosed.

Ann Intern Med. 2006;145(10):793-796. doi:10.7326/0003-4819-145-10-200611210-00024
Text Size: A A A

During the 1990s, the U.S. drug industry launched one big new drug after another—the list included statins, proton-pump inhibitors, antidepressants, osteoporosis therapies, and nonsedating antihistamines. Pharmaceutical companies predicted that the number of new drugs would continue to grow in the years to come, a prediction supported by the investment of more than $100 billion in drug research and development by the National Institutes of Health (NIH), public institutions, and private companies. Furthermore, scientific advances related to combinatorial chemistry, genomics, and proteomics promised to make drug discovery and development more efficient.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Our failure to provide drugs to developing countries
Posted on November 22, 2006
Kenneth A Hoekstra
Western States Chiropractic College
Conflict of Interest: None Declared

In Jennifer Wilson's article titled Alterations in Processes and Priorities Needed for New Drug Development, the author describes some of the failures of the pharmaceutical companies in drug discovery, development and distribution (1). All aspects of industrialized nations (i.e. medical, economic, business, political) have taken two steps backwards for each and every step forward in the promotion of drug discovery and/or distribution for developing countries (2-4). While it can be argued that pharmaceutical companies may have no special obligation to third world countries and drug discovery and distribution (5, 6), a greater obligation to do no harm, and promote and extend the fundamental rights and values that we (i.e. industrialized nations) cherish supersedes such philosophical thought. To this date, developed countries have failed (3).

1. Wilson JF. 2006. Alterations in Processes and Priorities Needed for New Drug Development. Ann Intern Med 145: 793-796.

2. Nyigo VA, Malebo HM. 2005. Drug discovery and developments in developing countries: bottlenecks and way forward.Tanzan Health Res Bull., 7(3):154-8.

3. O'dowd A. Doha Declaration has failed to deliver cheap drugs to developing countries, Oxfam says. 2006. BMJ, 333(7577): 1036.

4. Silversides A. Canada falters on promise of AIDS drugs for Africa. 2006. CMAJ, 175(7):726.

5. Lee Chang P.2006. Who's in the business of saving lives? J Med Philos. 31(5):465-82.

6. Ashcroft RE. 2005.Access to essential medicines: a Hobbesian social contract approach. Developing World Bioeth. 5(2):121-41.

Conflict of Interest:

None declared

Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.