0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

The Pathogenesis of Venous Thromboembolism: Evidence for Multiple Interrelated Causes

Jan-Leendert P. Brouwer, MD; Nic J.G.M. Veeger, MSc; Hanneke C. Kluin-Nelemans, MD, PhD; and Jan van der Meer, MD, PhD
[+] Article and Author Information

From University Medical Center Groningen, Groningen, the Netherlands.


Grant Support: None.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Jan van der Meer, MD, PhD, Department of Hematology, Division of Haemostasis, Thrombosis and Rheology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands; e-mail, j.van.der.meer@int.umcg.nl.

Current Author Addresses: Drs. Brouwer, Kluin-Nelemans, and van der Meer: Department of Hematology, Division of Haemostasis, Thrombosis and Rheology, University Medical Center Groningen, Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.

Mr. Veeger: Department of Epidemiology, Trial Coordination Center, University Medical Center Groningen, Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.

Author Contributions: Conception and design: J. van der Meer.

Analysis and interpretation of the data: J.-L.P. Brouwer, N.J.G.M. Veeger, H.C. Kluin-Nelemans, J. van der Meer.

Drafting of the article: J.-L.P. Brouwer.

Critical revision of the article for important intellectual content: N.J.G.M. Veeger, H.C. Kluin-Nelemans, J. van der Meer.

Final approval of the article: J.-L.P. Brouwer, N.J.G.M. Veeger, H.C. Kluin-Nelemans, J. van der Meer.

Provision of study materials or patients: J.-L.P. Brouwer, J. van der Meer.

Statistical expertise: N.J.G.M. Veeger.

Obtaining of funding: J. van der Meer.

Administrative, technical, or logistic support: J.-L.P. Brouwer.

Collection and assembly of data: J.-L.P. Brouwer, J. van der Meer.


Ann Intern Med. 2006;145(11):807-815. doi:10.7326/0003-4819-145-11-200612050-00005
Text Size: A A A

We aimed to assess interactions between known thrombophilic deficiencies and defects, including hereditary deficiencies of protein S, protein C, and antithrombin. Because these deficiencies are strong risk factors for VTE, the effects and clinical impact of interactions with more prevalent and mild thrombophilic defects may be more pronounced than interactions between mild defects. To enroll sufficient numbers of affected persons needed for accurate risk estimates, we identified families with these rare deficiencies. The family cohort study design enabled us to assess the clinical impact of interactions from absolute risk estimates.

First Page Preview

View Large
First page PDF preview

Figures

Grahic Jump Location
Figure 1.
Recruitment of 3 family cohorts with hereditary deficiencies of protein S, protein C, or antithrombin.
Grahic Jump Location
Grahic Jump Location
Figure 2.
Event-free survival in relatives with a deficiency of protein S, protein C, or antithrombin (index deficiency) and one or more additional thrombophilic deficiencies or defects.
Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clotting Disorders and Other Risk Factors for Venous Thromboembolism

The summary below is from the full report titled “The Pathogenesis of Venous Thromboembolism: Evidence for Multiple Interrelated Causes.” It is in the 5 December 2006 issue of Annals of Internal Medicine (volume 145, pages 807-815). The authors are J.-L.P. Brouwer, N.J.G.M. Veeger, H.C. Kluin-Nelemans, and J. van der Meer.

Read More...

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Inherited risk factors in low-risk venous thromboembolism in patients under 45 years. Interact Cardiovasc Thorac Surg Published online Oct 17, 2014.;
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)