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Survival of Persons with and without HIV Infection in Denmark, 1995–2005

Nicolai Lohse, MD, PhD; Ann-Brit Eg Hansen, MD; Gitte Pedersen, MD, PhD; Gitte Kronborg, MD, DMSc; Jan Gerstoft, MD, DMSc; Henrik Toft Sørensen, MD, PhD, DMSc; Michael Væth, PhD; and Niels Obel, MD, DrSci, DMSc
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From Odense University Hospital and University of Southern Denmark, Odense, Denmark; Århus University Hospital and Århus University, Århus, Denmark; Hvidovre University Hospital, Hvidovre, Denmark; Rigshospitalet, Copenhagen, Denmark; and Boston University, Boston, Massachusetts.

Acknowledgments: The authors thank the staff of their clinical departments for their continuous support and enthusiasm.

Grant Support: The Danish HIV Cohort study receives funding from the Danish AIDS Foundation, Odense University Hospital, Preben and Anna Simonsen's Foundation, the Foundation of the Danish Association of Pharmacists, and the Clinical Institute at the University of Southern Denmark.

Potential Financial Conflicts of Interest: Consultancies: J. Gerstoft (Roche, Glaxo, Abbott, Boehringer Ingelheim, Merck Sharp & Dohme, Swedish-Orphan Drugs); Honoraria: J. Gerstoft (Roche, Glaxo, Abbott, Boehringer Ingelheim, MSD, Swedish-Orphan Drugs); Grants received: N. Obel (Roche, Bristol-Meyers Squibb, Merck Sharp & Dohme, GlaxoSmithKline, Abbott, Boehringer Ingelheim, Janssen-Cilag, Swedish-Orphan Drugs).

Requests for Single Reprints: Nicolai Lohse, MD, PhD, Department of Infectious Diseases, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense C, Denmark; e-mail, nl@dce.au.dk.

Current Author Addresses: Drs. Lohse, Hansen, and Obul: Department of Infectious Diseases, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense C, Denmark.

Dr. Pedersen: Department of Infectious Diseases, Aalborg University Hospital, DK-9000 Aalborg, Denmark.

Dr. Kronborg: Department of Infectious Diseases, Hvidovre Hospital, DK-2650 Hvidovre, Denmark.

Dr. Gerstoft, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark.

Dr. Sørensen: Department of Clinical Epidemiology, Århus University Hospital, Ole Worms Allé 1150, DK-8000 Århus C, Århus, Denmark.

Dr. Væth: Department of Biostatistics, University of Århus, DK-8000 Århus C, Denmark.

Author Contributions: Conception and design: N. Lohse, A.-B.E. Hansen, H.T. Sørensen, N. Obel.

Analysis and interpretation of the data: N. Lohse, H.T. Sørensen, M. Væth, N. Obel.

Drafting of the article: N. Lohse.

Critical revision of the article for important intellectual content: N. Lohse, A.-B.E. Hansen, G. Pedersen, G. Kronborg, J. Gerstoft, H.T. Sørensen, M. Væth, N. Obel.

Final approval of the article: N. Lohse, A.-B.E. Hansen, G. Pedersen, G. Kronborg, J. Gerstoft, H.T. Sørensen, M. Væth, N. Obel.

Provision of study materials or patients: G. Pedersen, G. Kronborg, J. Gerstoft, N. Obel.

Statistical expertise: N. Lohse, M. Væth.

Obtaining of funding: N. Obel.

Administrative, technical, or logistic support: N. Lohse, N. Obel.

Collection and assembly of data: N. Lohse, A.-B.E. Hansen, G. Kronborg, J. Gerstoft, N. Obel.

Ann Intern Med. 2007;146(2):87-95. doi:10.7326/0003-4819-146-2-200701160-00003
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In this population-based cohort study, we estimate a median remaining lifetime of more than 35 years for a 25-year-old, HIV-positive person without HCV infection who received care in the twenty-first century. We expect this estimate to be robust because the study included all patients, regardless of such prognostic factors as CD4-positive cell count, HIV RNA, disease stage, history of AIDS, treatment adherence, or time receiving HAART. The increase in survival over time was attributable mainly to a decrease in HIV-related deaths. Despite the encouraging survival expectations, the study still shows large, age-dependent excess mortality rates in the HIV-infected cohort compared with the general population. The excess mortality rates increased with increasing age, whereas the relative mortality rates decreased.

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Survival from age 25 years.

Cumulative survival curve for HIV-infected persons (without hepatitis C coinfection) and persons from the general population. Persons with HIV infection are divided into 3 calendar periods of observation. Dashed lines indicate 95% CIs. HIV = human immunodeficiency virus; HAART = highly active antiretroviral therapy.

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Summary for Patients

Comparison of Survival among HIV-Infected and Noninfected People in Denmark, 1995–2005

The summary below is from the full report titled “Survival of Persons with and without HIV Infection in Denmark, 1995–2005.” It is in the 16 January 2007 issue of Annals of Internal Medicine (volume 146, pages 87-95). The authors are N. Lohse, A.-B.E. Hansen, G. Pedersen, G. Kronborg, J. Gerstoft, H.T. Sørensen, M. Væth, and N. Obel.


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