Patients were randomly assigned to receive either a sequential regimen or a standard regimen (the standard regimen is approved by the U.S. Food and Drug Administration). The sequential regimen was pantoprazole, amoxicillin, and placebo for 5 days followed by pantoprazole, clarithromycin, and tinidazole for 5 days. The standard regimen was pantoprazole, clarithromycin, and amoxicillin for 10 days. Four and 8 weeks after treatment, all patients were checked for H. pylori infection with urea breath tests. If the results of both tests were negative, researchers concluded that the infection was cured or eradicated. They then compared cure rates between groups. During the study, researchers, doctors, and patients did not know which treatment each patient received.