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Anti–Cyclic Citrullinated Peptide Antibodies in the Diagnosis of Rheumatoid Arthritis: Bayes Clears the Haze

Axel Finckh, MD, MS; and Matthew H. Liang, MD, MPH
[+] Article, Author, and Disclosure Information

From University Hospital of Geneva, CH-1211 Geneva 14, Switzerland, and Brigham and Women's Hospital, Boston, MA 02115.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Axel Finckh, MD, MS, Division of Rheumatology, University Hospital of Geneva, Avenue Beau-Séjour 26, CH-1211 Geneva 14, Switzerland; e-mail, axel.finckh@hcuge.ch.

Current Author Addresses: Dr. Finckh: Division of Rheumatology, University Hospital of Geneva, Avenue Beau-Séjour 26, CH-1211 Geneva 14, Switzerland.

Dr. Liang: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, 75 Francis Street, P.B.B. 3, Boston, MA 02115.

Ann Intern Med. 2007;146(11):816-817. doi:10.7326/0003-4819-146-11-200706050-00011
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In this issue, Nishimura and colleagues review the value of testing for anti–cyclic citrullinated peptide (CCP) antibodies in the diagnosis of rheumatoid arthritis (1). Their well-done meta-analysis confirms that the presence of anti-CCP antibody is more specific than rheumatoid factor for diagnosing rheumatoid arthritis and thereby corroborates the results of 2 published systematic reviews (23).

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