The USPSTF bases its recommendations on systematic evidence reviews, which form the critical underpinnings of its deliberations and decision making. The USPSTF members are intensively involved in the conceptualization, content, and interpretation of these reviews. The reviews are products of a partnership between members of the USPSTF and Evidence-based Practice Center (EPC), which conducts, synthesizes, and produces them. The process is facilitated and coordinated by the staff of the AHRQ, and in some cases, the AHRQ staff conducts targeted evidence updates. The USPSTF now uses 4 types of reviews to support its recommendations: full evidence reviews, staged evidence reviews, targeted evidence updates, and reaffirmation updates. Recommendations for new topics are informed by full evidence reviews (which may be, in rare instances, staged evidence reviews). Updates of previous recommendations are informed by 1 of 3 types of reviews: full evidence updates, targeted evidence updates, or reaffirmation updates. These 3 updated reviews represent a new methodology for the USPSTF process. Table 3 provides descriptions and examples of the types of reviews.