While recognizing these shortcomings of existing systematic reviews, how can we encourage clinicians and policymakers to use them? First, we could provide more exposure to systematic reviews (which, despite their length and apparent complexity, are relatively easy to interpret) during clinical training. Second, we could encourage more interaction among researchers, policymakers, and frontline clinicians, so that trialists might design pragmatic studies aimed at answering questions of interest to policymakers and clinicians. Third, policymakers must be more willing to commission randomized trials of policy-relevant questions, which can then be incorporated into systematic reviews. Fourth, the authors of systematic reviews should provide more contextual information or refer readers to easy-to-find articles that contain this information. Finally, authors must develop user-friendly formats so that busy clinicians and health care managers can use systematic reviews in real-time decision making. We suggest making systematic reviews available in 3 formats: 20-second, 2-minute, and 2-hour versions. The 20-second version is a 1-paragraph to 1-page bottom-line summary. The 2-minute version is a 2- to 3-page summary that focuses on details of validity and applicability (with sufficient information to facilitate implementation of the evidence). The 2-hour version contains all of the relevant methodological and contextual details.