0
Summaries for Patients |

Long-Term Use of Selenium Supplements and Risk for Type 2 Diabetes FREE

[+] Article and Author Information

The summary below is from the full report titled “Effects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes. A Randomized Trial.” It is in the 21 August 2007 issue of Annals of Internal Medicine (volume 147, pages 217-223). The authors are S. Stranges, J.R. Marshall, R. Natarajan, R.P. Donahue, M. Trevisan, G.F. Combs, F.P. Cappuccio, A. Ceriello, and M.E. Reid.


Ann Intern Med. 2007;147(4):I-14. doi:10.7326/0003-4819-147-4-200708210-00176
Text Size: A A A

What is the problem and what is known about it so far?

Selenium is a mineral that is required in very low doses for the body to function normally. It is an antioxidant, meaning that it prevents oxygen from damaging cells. Although most people get enough selenium in their diet, selenium is included in many multivitamins and is sold as a supplement itself. Many people take selenium supplements to stay healthy. Some research suggests that selenium supplements can improve the way the body handles sugar and might prevent some complications of diabetes. However, other research suggests that selenium supplementation has no effect on diabetes or health.

Why did the researchers do this particular study?

To see whether taking selenium supplements prevents diabetes.

Who was studied?

1202 people with skin cancer other than melanoma who were seen in dermatology clinics in areas of the United States where people tend to have low blood levels of selenium. None of the participants had diabetes.

How was the study done?

The researchers measured participants' blood selenium levels. They then randomly assigned the participants to take selenium supplements (200 micrograms) or placebo pills. They followed the participants over an average of 7 years to see who developed diabetes. They then compared the number of people with diabetes in the 2 groups.

What did the researchers find?

More people who took selenium developed diabetes than those who took placebo pills. The risk for diabetes seemed to be higher in people who had higher blood selenium levels at the start of the study.

What were the limitations of the study?

The researchers relied on participants' reports that they developed diabetes and did not confirm those reports with measures of blood sugar. The findings apply to the specific dose of selenium used in the study. Participants tended to be older and white, so the findings might not apply to younger people and those of other races.

What are the implications of the study?

Selenium supplements appear to increase the risk for diabetes. Although the findings need to be confirmed, long-term selenium supplementation should not be viewed as harmless and a possibly healthy way to prevent illness.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)