The full content of Annals is available to subscribers

Subscribe/Learn More  >
In the Clinic |


Jennifer F. Wilson
Ann Intern Med. 2007;147(9):ITC11-1. doi:10.7326/0003-4819-147-9-200711060-01011
Text Size: A A A

Migraine headache affects 18% of women and 6% of men. Three quarters of migraine sufferers have moderate-to-severe symptoms that interfere with work, school, and other normal daily activities. Despite being a significant cause of episodic but disabling symptoms, the condition remains underrecognized, underdiagnosed, and undertreated. Migraine pain was previously believed to be largely vascular in cause, but evidence now shows that it involves genetic control of the activity of some brain cells. It is hypothesized that migraine activity begins in the brainstem and ends with distention and inflammation of meningeal vessels. These events cause an instability in brain cells that triggers surges of abnormal impulses to the periphery and releases inflammatory substances. Although migraines can be highly disruptive to daily life, effective behavioral and drug treatments can prevent attacks or relieve symptoms.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.