The SFGH HIV clinic is located in a ZIP code with high prevalence of multidrug-resistant USA300 (Figure). The 183 consecutive patients with MRSA infection treated at the SFGH HIV clinic were predominantly male (85%), white (54%), and men who have sex with men (69%) and had a median age of 40 years (interquartile range, 34 to 47 years). Most (n = 179) had skin and soft tissue infections that manifested as an abscess (n = 121), cellulitis (n = 17), folliculitis (n = 18), impetigo (n = 2), ulceration (n = 6), and wound infection (n = 15). The remaining 4 patients had non–multidrug-resistant USA300 or non-USA300 infection that manifested as joint infection, acute sinusitis, bloodstream infection, and pneumonia. Forty-five (25%) patients had infections involving the buttocks, genitals, or perineum (buttocks [n = 27], scrotum [n = 6], penis [n = 5], perianal area [n = 3], pubic region [n = 2], rectum [n = 1], and vulva [n = 1]).