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Effect of Glucosamine Sulfate on Hip Osteoarthritis: A Randomized Trial

Rianne M. Rozendaal, MSc; Bart W. Koes, PhD; Gerjo J.V.M. van Osch, PhD; Elian J. Uitterlinden, MD, PhD; Eric H. Garling, PhD; Sten P. Willemsen, MSc; Abida Z. Ginai, MD; Jan A.N. Verhaar, MD, PhD; Harrie Weinans, PhD; and Sita M.A. Bierma-Zeinstra, PhD
[+] Article, Author, and Disclosure Information

From Erasmus Medical Center, Rotterdam, the Netherlands, and Leiden University Medical Center, Leiden, the Netherlands.

Acknowledgment: The authors thank all the patients who participated in the trial and the general practitioners responsible for their recruitment. They also thank Diana van Emmerik for her contribution to the success of the trial.

Grant Support: By the Erasmus Medical Center–Breedtestrategie program.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Rianne M. Rozendaal, MSc, Department of General Practice, Erasmus Medical Center, Room Fg 351, PO Box 2040, 3000 CA Rotterdam, the Netherlands; e-mail, r.rozendaal@erasmusmc.nl.

Current Author Addresses: Ms. Rozendaal; Drs. Koes and Bierma-Zeinstra; and Mr. Willemson: Department of General Practice, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands.

Drs. van Osch, Uitterlinden, Verhaar, and Weinans: Department of Orthopaedics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands.

Dr. Garling: Department of Orthopaedics, Biomechanics and Imaging Group, Leiden University Medical Center, PO Box 9600, J11-S, 2300 RC Leiden, the Netherlands.

Dr. Ginai: Department of Radiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands.

Author Contributions: Conception and design: B.W. Koes, G.J.V.M. van Osch, E.J. Uitterlinden, H. Weinans, S.M.A. Bierma-Zeinstra.

Analysis and interpretation of the data: R.M. Rozendaal, S.M.A. Bierma-Zeinstra.

Drafting of the article: R.M. Rozendaal, S.M.A. Bierma-Zeinstra.

Critical revision of the article for important intellectual content: B.W. Koes, G.J.V.M. van Osch, E.J. Uitterlinden, A.Z. Ginai, J.A.N. Verhaar, H. Weinans, S.M.A. Bierma-Zeinstra.

Final approval of the article: B.W. Koes, G.J.V.M. van Osch, E.H. Garling, A.Z. Ginai, J.A.N. Verhaar, S.M.A. Bierma-Zeinstra.

Statistical expertise: S.P. Willemsen.

Obtaining of funding: H. Weinans, S.M.A. Bierma-Zeinstra.

Administrative, technical, or logistic support: E.J. Uitterlinden.

Collection and assembly of data: R.M. Rozendaal, E.H. Garling.

Ann Intern Med. 2008;148(4):268-277. doi:10.7326/0003-4819-148-4-200802190-00005
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We did not find glucosamine sulfate to be more effective than placebo in modifying the symptomatic and radiographic progression of hip osteoarthritis over 24 months of daily therapy.

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Grahic Jump Location
Figure 1.
Study flow diagram.

THA = total hip arthroplasty.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Expected mean Western Ontario and McMaster Universities (WOMAC) pain and error scores, by treatment group.

P = 0.44 for difference between glucosamine sulfate and placebo groups over 2 years.

Grahic Jump Location




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Summary for Patients

Glucosamine Sulfate to Treat Hip Osteoarthritis

The summary below is from the full report titled “Effect of Glucosamine Sulfate on Hip Osteoarthritis. A Randomized Trial.” It is in the 19 February 2008 issue of Annals of Internal Medicine (volume 148, pages 268-277). The authors are R.M. Rozendaal, B.W. Koes, G.J.V.M. van Osch, E.J. Uitterlinden, E.H. Garling, S.P. Willemsen, A.Z. Ginai, J.A.N. Verhaar, H. Weinans, and S.M.A. Bierma-Zeinstra.


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